56791-25-4

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 105-36-2 ethyl bromoacetate 
• 6048-06-2 ethyl-p-chlorocinnamate 
• 21911-74-0 (methyl-phenyl-amino)-acetic acid ethyl ester 

Downstream Products

• 85174-84-1 trans-4-(4-Chlorphenyl)-2-oxooxazolidin-5-carbonsaeure-ethylester 
• 85174-84-1 cis-4-(4-Chlorphenyl)-2-oxooxazolidin-5-carbonsaeure-ethylester 
• 85174-82-9 trans-5-(4-Chlorphenyl)-2-oxooxazolidin-4-carbonsaeure-ethylester 
• 85174-82-9 cis-5-(4-Chlorphenyl)-2-oxooxazolidin-4-carbonsaeure-ethylester 

Relevant academic research and scientific papers

Efficient protocol for stereoselective epoxidation of cinnamic esters using TsNBr2

An efficient method has been developed for the synthesis of epoxide from cinnamic esters without any catalyst. The reaction was performed in CH 3CN-water (4:1) using N,N-dibromo-p-toluenesulfonamide (TsNBr 2) in alkaline conditions. This procedure can be utilized for stereoselective synthesis of epoxides from cinnamic esters in excellent yield in a shorter reaction time with exclusive formation of the trans-isomer. The method was further extended successfully for styrenes. Taylor & Francis Group, LLC.

Facile construction of three-membered rings via benzyne-promoted Darzens-type reaction of tertiary amines

A range of tertiary amines having electron-withdrawing groups were activated in situ by benzyne, generated from 2-(trimethylsilyl)phenyl triflate and a fluoride source, and participated in the Darzens-type reaction with carbonyl compounds, imines, and vinyl ketones to afford structurally diverse epoxides, aziridines, and cyclopropanes, respectively, in moderate to excellent yields with high trans-selectivity. The reaction involves in situ formation of unstrained ammonium ylides from tertiary amines and benzyne, proceeds in the absence of transition metals and strong bases, and tolerates a wide variety of functional groups.

NEW SYNTHETIC ROUTES TO β-FLUORO β-PHENYLLACTIC ACID DERIVATIVES AND Β-FLUOROCYANOHYDRINS

Alkyl phenyl 2,3-epoxycarboxylates from the well-known Darzens glycidic esters synthesis react under very mild conditions with pyridinium-poly-hydrogen fluoride to give corresponding 3-fluoro 3-phenyllactates in almost quantitative yields with a high regio and stereoselectivity.This method can be applied succesfully to other flycidic derivatives: glycidoamides, glycidonitriles, glycidoiminoesters...The spectrometric properties (IR, NMR) are presented.