56796-20-4 Usage
Description
Cefmetazole is a cephamycin with a nonaromatic side chain at C-7. In addition to a fairly characteristic
second-generation cephalosporin antimicrobial spectrum, it possess fairly significant anti-antiaerobic
activity. The ejection of its C-3 side chain leads to alcohol intolerance of the disulfuram type and prolonged
clotting times.
Chemical Properties
White Solid
Uses
Different sources of media describe the Uses of 56796-20-4 differently. You can refer to the following data:
1. Semi-synthetic antibiotic derived from Cephamycin. Antibacterial.
2. A broad spectrum second generation cephalosporin antibiotic
Definition
ChEBI: A cephalosporin antibiotic containg an N1-methyltetrazol-5-ylthiomethyl side-chain at C-3 of the parent cephem bicyclic structure.
Antimicrobial activity
It is active
against Pr. mirabilis, Pr. vulgaris, Morganella morganii, Yersinia spp.and most anaerobes. S. marcescens is moderately susceptible,
but Ps. aeruginosa and E. faecalis are resistant. It is active against
Mycobacterium fortuitum and some strains of M. chelonei. It is
resistant to a wide range of β-lactamases.
The serum concentration at the end of a 1 g intravenous
infusion is around 77 mg/L. Plasma protein binding is 68%. It
is principally excreted in the urine with a plasma half-life of c.
1.3 h; 70% is recovered over the first 6 h. In patients whose
creatinine clearance is less than 10 mL/min, plasma levels are
elevated and the plasma half-life is increased to around 15 h.
Side effects associated with the methylthiotetrazole group
at position C-3 have been reported. Uses are similar to those
of cefoxitin, but it is not widely available.
Check Digit Verification of cas no
The CAS Registry Mumber 56796-20-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,7,9 and 6 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 56796-20:
(7*5)+(6*6)+(5*7)+(4*9)+(3*6)+(2*2)+(1*0)=164
164 % 10 = 4
So 56796-20-4 is a valid CAS Registry Number.
InChI:InChI=1/C15H17N7O5S3/c1-21-14(18-19-20-21)30-6-8-5-29-13-15(27-2,17-9(23)7-28-4-3-16)12(26)22(13)10(8)11(24)25/h13H,4-7H2,1-2H3,(H,17,23)(H,24,25)/t13-,15+/m1/s1
56796-20-4Relevant articles and documents
Method for preparing cefmetazole acid
-
, (2018/04/03)
The invention relates to a method for preparing cefmetazole acid and belongs to the technical field of preparation of cephalosporin compounds. The method for preparing the cefmetazole acid disclosed by the invention comprises the following steps: taking 7beta-amino-3-(1-methyl-1H-tetrazole-5-S-methyl)-3-cephem-4-carboxylic acid (3-TZ) as an initial raw material, performing silanization protectionon carboxyl and amino, and performing methylation, condensation and acid hydrolysis reaction, thereby obtaining cefmetazole acid. The method disclosed by the invention is simple in process, low in cost and less in steps, ensure high product yield and purity, has energy-saving and environmental-friendly effects, adopts a recyclable solvent and thus is suitable for industrialized production.
Prodrug derivatives of carboxylic acid drugs
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, (2008/06/13)
Novel ester derivatives of carboxylic acid medicaments of formula (I), wherein R--COO--represents the acyloxy residue of a carboxylic acid drug or medicament, n is an integrer from 1 to 3, and R1 and R2 are the same or different and are selected from a group consisting of an alkyl, an alkenyl, an aryl, an aralkyl, a cycloalkyl and which group may be unsubstituted or substituted, or R1 and R2 together with the N forms a 4-, 5-, 6- or 7-membered heterocyclic ring, which in addition to the nitrogen atom may contain one or two further heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur and which heterocyclic group may be substituted. These compounds are highly biolabile prodrug forms of the corresponding carboxylic acid compounds and are highly susceptible to undergoing enzymatic hydrolysis in vivo whereas they are highly stable in aqueous solution. The novel derivatives are less irritating to mucosa than the parent carboxylic acids and may provide an improved bio-availability of the drugs.
Synthesis of 7α substituted cephalosporins. V. Novel oxidation procedure for syntheses of 7α methoxycephalosporins and 6α methoxypenicillins
Yanagisawa,Fukushima,Ando,Nakao
, p. 969 - 972 (2007/10/07)
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