56800-32-9

Upstream product

• 15872-42-1 4-heptyloxybenzoic acid 
• 123-08-0 4-hydroxy-benzaldehyde 
• 40782-54-5 4-heptyloxybenzoyl chloride 
• 629-04-9 1-Bromoheptane 
• 108-95-2 phenol 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 154845-73-5 4-heptyloxy-benzoic acid ethyl ester 
• 629-06-1 1-Chloroheptane 
• 27893-41-0 4-(n-heptyloxy)benzaldehyde 
• 16782-08-4 sel de potassium de l'acide p-hydroxybenzoique 
• 99-96-7 4-hydroxy-benzoic acid 

Downstream Products

• 93959-46-7 4-Heptyloxy-benzoic acid 4-[4-oxo-2-thioxo-thiazolidin-(5Z)-ylidenemethyl]-phenyl ester 
• 79612-72-9 4-Heptyloxy-benzoic acid 4-[(E)-octyliminomethyl]-phenyl ester 
• 108532-21-4 4-Heptyloxy-benzoic acid 4-{[(E)-4-butoxy-phenylimino]-methyl}-phenyl ester 
• 102091-60-1 4-Heptyloxy-benzoic acid 4-{[(E)-4-decyloxy-phenylimino]-methyl}-phenyl ester 
• 108532-23-6 4-Heptyloxy-benzoic acid 4-{[(E)-4-hexyloxy-phenylimino]-methyl}-phenyl ester 
• 108532-24-7 4-Heptyloxy-benzoic acid 4-{[(E)-4-heptyloxy-phenylimino]-methyl}-phenyl ester 
• 104348-26-7 4-Heptyloxy-benzoic acid (2R,4aR,8aS)-4-(hexahydro-benzo[1,3]dioxin-2-yl)-phenyl ester 
• 108532-26-9 4-Heptyloxy-benzoic acid 4-{[(E)-4-nonyloxy-phenylimino]-methyl}-phenyl ester 
• 79612-71-8 4-Heptyloxy-benzoic acid 4-[(E)-pentyliminomethyl]-phenyl ester 
• 77923-00-3 4-Heptyloxy-benzoic acid 4-{[(E)-4-ethoxy-phenylimino]-methyl}-phenyl ester 
• 69452-74-0 4-Heptyloxy-benzoic acid 4-{[(E)-4-ethyl-phenylimino]-methyl}-phenyl ester 

Relevant academic research and scientific papers

2-Aryl benzazole derived new class of anti-tubercular compounds: Endowed to eradicate mycobacterium tuberculosis in replicating and non-replicating forms

The high mortality rate and the increasing prevalence of Mtb resistance are the major concerns for the Tuberculosis (TB) treatment in this century. To counteract the prevalence of Mtb resistance, we have synthesized 2-aryl benzazole based dual targeted molecules. Compound 9m and 9n were found to be equally active against replicating and non-replicating form of Mtb (MIC(MABA) 1.98 and 1.66 μg/ml; MIC(LORA) 2.06 and 1.59 μg/ml respectively). They arrested the cell division (replicating Mtb) by inhibiting the GTPase activity of FtsZ with IC50 values 45 and 64 μM respectively. They were also capable of kill Mtb in non-replicating form by inhibiting the biosynthesis of menaquinone which was substantiated by the MenG inhibition (IC50 = 11.62 and 7.49 μM respectively) followed by the Vit-K2 rescue study and ATP production assay.

Effect of the Functional Groups of Racemic Rodlike Schiff Base Mesogens on the Stabilization of Blue Phase in Binary Mixture Systems

Four series of rodlike racemic Schiff base mesogens possessing different alkyl chains and two types of linkages, ester and alkynyl linkages, were synthesized and applied to induce cubic blue phases (BPs) in simple binary mixture systems. The mesophases of these Schiff base mesogens were confirmed by variable-temperature X-ray diffraction and the characteristic texture from polarized optical microscopy (POM). In general, when chiral additive S-(+)-2-octyl 4-(4-hexyloxybenzoyloxy)benzoate (S811; 20-40 wt %) is added into the rodlike racemic salicylaldimine-based mesogens, the cubic BPs could be observed and its temperature range is larger than 20 K. The widest temperature range of the cubic BP (35 K) can be observed in the blending mixture composed of rodlike racemic salicylaldimine-based mesogen OH-TIn possessing alkynyl linkage and 35-40 wt % S811. However, Schiff base mesogens possessing alkynyl linkage show a direct isotropic to chiral nematic transition when equal amount of chiral dopant is added. Notably, the termination temperature of BPs is very close to room temperature (ca. 35 °C) after 40.0 wt % S811 is added into the salicylaldimine-based mesogens possessing terminal alkyl chains and ester linkage. Interestingly, wide BPs (>30 K) can also be induced by adding chiral additive 1,4:3,6-dianhydro-2,5-bis[4-(n-hexyl-1-oxy)benzoic acid]sorbitol (ISO(6OBA)2) with a high helical twisting power into the racemic Schiff base mesogen possessing ester linkage. Cubic BPI and BPII can be confirmed by reflectance spectra and POM. The results of reflectance spectra indicate that the binary mixture composed of salicylaldimine-based mesogens and S811 easily exhibits a supercooling effect and induces BPI. However, only BPII can be observed in all binary mixtures containing Schiff base mesogens. On the basis of our experimental results and molecular modeling, we suppose that the values of biaxiality, polarizability, and the dipole moment of molecular geometry are the main factors that affect BP stabilization.

Synthesis and mesomorphic investigations of liquid crystalline compounds having a benzothiazole ring

Two homologous series of calamitic liquid crystals containing a benzothiazole ring and two different linkages have been prepared, and their liquid crystalline properties are studied and compared with each other and those of similar structure. The mesogens with only the cinnamate linking group showed better thermal properties than those with an ester. Nematic and smectic phases were observed. All the compounds of both the series were characterized by elemental analysis, FT-IR, mass spectrometry, 1H-NMR, and 13C-NMR. Phase transition temperatures and the thermal parameters were obtained from differential scanning calorimetery (DSC). The textural observations were performed using hot-stage Polarizing Optical Microscopy (POM).

Synthesis and comparative study on phase transition behavior of triazole-cored liquid crystals armed with cholesterol and double or triple aromatic rings systems

Two homologous series of optically active bent-shaped mesogens comprising a cholesterol unit as one of the side arms connected to a 1,2,3-triazole ring while the other arm of the triazole ring is connected to two- and three-ring aromatic systems with varying terminal chain lengths have been synthesized. The molecular structure, thermal and optical activities have been studied extensively in which the compounds from both series exhibit polymorphism ranging from chiral nematic (N*), chiral smectic A (SmA*), chiral smectic C (SmC*) and twist grain boundary (TGBC*) phases. A further comparison between the two series of target compounds has drawn a common remark of which the phase behavior is found to be dependent on the length of the terminal tail and number of aromatic rings in the mesogenic units.

Synthesis, characterization and mesomorphic properties of new rod-like thiophene based liquid crystals

Two new mesogenic homologous series of Schiff base esters, 2-[4-(4-n-Alkoxy benzoyloxy) benzylidenamino] 3-cyno thiophine (Series-A) and Schiff base cinnamates, 2-[4-(4-n-alkoxy cinnamoyloxy) benzylidenamino] 3-cyano thiophene (Series-B), comprising a thiophene moiety were synthesized. Structural elucidation was carried out using elemental analysis and spectroscopic techniques such as FT-IR, 1H-NMR and 13C-NMR, and mass spectrometry. The mesomorphic properties and thermal stabilities of the title compounds were studied by using differential scanning calorimetry and optical polarizing microscopy. All the derivatives are mesomorphic in nature showing the nematic phase, and the higher members of Series-A show a smectic C phase whereas Series-B exhibits only the nematic mesophase. The mesomorphic properties of the present series are compared with other structurally related compounds. Taylor and Francis Group, LLC.

NOVEL GLP-1 RECEPTOR STABILIZERS AND MODULATORS

Compounds that bind the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, methods of their therapeutic and/or prophylactic use, and methods of their use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor are provided. Certain compounds may have activity as modulators or potentiators with respect to glucagon receptor, GIP receptor, GLP-1 and GLP-2 receptors, and PTH receptor on their own or in the presence of receptor ligands such as GIP(1-42), PTH(1-34), Glucagon(1-29), GLP-2(1-33), GLP-1 (7-36), GLP-1 (9-36), oxyntomodulin and exendin variants.

Electro-optical switching studies on 1,3-phenylene based banana shaped liquid crystals

This work deals with the study of the thermotropic liquid crystalline properties of new asymmetric bent core liquid crystals. The thermotropic properties was analyzed by polarized optical microscopy, differential scanning calorimetric analysis and variable temperature X-ray diffraction measurements. Effect of equal terminal chain with asymmetric bent core system on mesomorphic behavior was examined. The shorter methyl chain compound 10a of exhibits B 1 mesophase and higher homologs (10b and 10c) shows antiferroelectric B2 mesophases, which was studied by electro-optical measurements.

A new way to access chiral liquid crystals: Organocatalyst-mediated synthesis of chiral rod-like liquid crystals

In this article, an asymmetric organocatalytic way to prepare chiral liquid crystals from non-chiral starting materials was described. By using L-proline as the organocatalyst, several new chiral rod-like liquid crystals that are elusive with traditional methods were prepared. In addition, a series of novel enone-containing rod-like liquid crystals were also obtained as side-products. Mesomorphic properties of all new compounds were studied by Polarized Optical Microscope and Differential Scanning Calorimetry. Copyright Taylor & Francis Group, LLC.

Liquid crystalline properties of 3-[4-(4′- alkoxybenzoyloxybenzylidene) amino]-1,2,4-triazines: Synthesis and characterization

A new series of 3-[4-(4′-alkoxybenzoyloxybenzylidene)amino]-1,2,4- triazines, C3H2N3N=CHC6H 4OCOC6H4OCmH2m+1 where m=6, 7, 8, 9, 10, 11, 12, 14, and 16 have been synthesized. These compounds have been characterized by elemental analyses, FT-IR, UV-visible, 1H, and 13C NMR spectroscopy. Mesomorphic properties of these compounds were studied by differential scanning calorimetry and polarizing microscopy. The mesomorphic nature of these compounds is dependent on the alkoxy chain length. The compounds (m=6, 7) do not exhibit mesomorphism while the compounds (m=8, 9, 11, 12, 14) show a monotropic nematic mesophase in cooling cycle. The 3-[4-(4′-decyloxybenzoyloxybenzylidene)amino]-1,2,4-triazine displays an enantiotropic nematic mesophase and the hexadecyloxy compound exhibits the smectic A mesophase. Copyright Taylor & Francis Group, LLC.

Liquid crystalline properties of unsymmetrical N-(o-hydroxybenzylidene)- N′-(4-n-alkoxybenzoyloxybenzylidene)azines: Synthesis and characterization

A new series of mesogenic unsymmetrical azines, N-(o-hydroxybenzylidene)- N′-(4-n-alkoxybenzoyloxybenzylidene)azines, HOC6H 4CH=N-N=CHC6H4OCOC6H4O CmH2m+1 (m=7, 8, 9, 10, 11, 12, 14, and 16) have been prepared. They have been characterized by elemental analyses, FT-IR, UV-visible, 1H, and 13C NMR (Nuclear Magnetic Resonance) spectra. The mesomorphic properties of these compounds were investigated by differential scanning calorimetry (DSC) and polarized optical microscopy (POM). The azines m=7, 10, and 14 exhibit features of enantiotropic nematic (N) mesophase whereas azines m=8, 11 exhibit features of a monotropic nematic phase. The azines m=9, 12, and 16 do not exhibit mesogenic nature. Copyright Taylor & Francis Group, LLC.