56814-11-0

Basic information

• Product Name: 2-AMINO-N-CYCLOHEXYLBENZAMIDE
• Synonyms: AKOS BBB/033;2-AMINO-N-CYCLOHEXYLBENZAMIDE;benzamide, 2-amino-N-cyclohexyl-;2-(Cyclohexylcarbamoyl)aniline, [(2-Aminobenzoyl)amino]cyclohexane;A2345/0099023;ARONIS006299;Maybridge1_003298;Oprea1_673490
• CAS NO: 56814-11-0
• Molecular Formula: C₁₃H₁₈N₂O
• Molecular Weight: 218.29
• Mol File: 56814-11-0.mol
• Article Data: 21

Chemical Properties

• Melting Point: 153-156°C
• Boiling Point: 421.5 °C at 760 mmHg
• Flash Point: 208.7 °C
• Appearance: /
• Density: 1.11 g/cm³
• Vapor Pressure: 2.59E-07mmHg at 25°C
• Refractive Index: 1.575
• PKA: 14.31±0.20(Predicted)
• CAS DataBase Reference: 2-AMINO-N-CYCLOHEXYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-CYCLOHEXYLBENZAMIDE(56814-11-0)
• EPA Substance Registry System: 2-AMINO-N-CYCLOHEXYLBENZAMIDE(56814-11-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 56814-11-0(Hazardous Substances Data)

Usage

General Description

2-Amino-N-cyclohexylbenzamide is a chemical compound with the molecular formula C13H17N3O. It is a white solid with a molecular weight of 231.29 g/mol. 2-AMINO-N-CYCLOHEXYLBENZAMIDE is commonly used in organic synthesis and pharmaceutical research as an intermediate. It possesses an amine group and a benzamide group, making it a potential candidate for drug development and medicinal chemistry. Additionally, 2-Amino-N-cyclohexylbenzamide has been studied for its potential biological activities, including its potential as an antitumor agent and its ability to inhibit certain enzymes. Further research is needed to fully understand and exploit the potential applications of this compound.

InChI:InChI=1/C13H18N2O/c14-12-9-5-4-8-11(12)13(16)15-10-6-2-1-3-7-10/h4-5,8-10H,1-3,6-7,14H2,(H,15,16)

Upstream product

• 91-56-5 indole-2,3-dione 
• 108-91-8 cyclohexylamine 
• 271-58-9 anthranil 
• 21563-73-5 2-aminobenzoyl chloride 
• 118-92-3 anthranilic acid 
• 28144-70-9 anthranilic acid amide 
• 491-36-1 4-Hydroxyquinazoline 
• 60007-51-4 3-(2-oxo-2-phenylethyl)quinazolin-4(3H)-one 
• 118-48-9 isatoic anhydride 

Downstream Products

• 142141-42-2 2-((cyclohexylamino)methyl)aniline 
• 5943-92-0 3-cyclohexyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline 
• 950-31-2 1H-spiro(cyclohexane-1,2-quinazolin)-4(3H)-one 
• 348612-65-7 N-cyclohexyl-2-(methylamino)benzamide 
• 14663-51-5 3-cyclohexylquinazolin-4(3H)-one 
• 1308660-41-4 6-cyclohexyl-6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione 
• 1542097-99-3 3-cyclohexyl-2-(5-ethylthiophen-2-yl)-2,3-dihydroquinazolin-4(1H)-one 

Relevant articles and documents

N,N-Dimethylformamide as Carbon Synthons for the Synthesis ofN-Heterocycles: Pyrrolo/Indolo[1,2-a]quinoxalines and Quinazolin-4-ones

N,N-dimethylformamide (DMF) as synthetic precursors contributing especially the methyl, acyl, and amino groups has played a significant role in heterocycle syntheses and functionalization. In this protocol, a wide range of pyrrolo/indolo[1,2-a]quinoxalines and quinazolin-4-ones were obtained in moderate to good yields by using elemental iodine without any metal or peroxides. We considered thatN-methyl andN-acyl of DMF participate and complete the reaction separately through different mechanisms, which displayed potential still to be explored of DMF.

Synthesis of new di- And triamides as potential organocatalysts for asymmetric aldol reaction in water

New di- or triamide organocatalysts derived from (L)-proline were synthesized and successfully used in the direct asymmetric aldol reaction of aliphatic ketones and aromatic aldehydes in water at 0 °C in the presence of benzoic acid as co-catalyst. (S)-me

NaNO2/I2 as an alternative reagent for the synthesis of 1,2,3-benzotriazin-4(3H)-ones from 2-aminobenzamides

An efficient transformation of 2-aminobenzamides to 1,2,3-benzotriazin-4(3H)-ones in the presence of sodium nitrite (NaNO2) and Iodine (I2) is described. The reaction is proposed to proceed via formation of nitrosyl halide that induces nitrosylation of the amino group of 2-aminobenzamide leading to diazotization followed by intramolecular cyclization.