56830-41-2

Upstream product

• 1073-13-8 4,4-dimethylcyclohexenone 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 5804-85-3 diethylaluminium cyanide 
• 151-50-8 potassium cyanide 

Downstream Products

• 623563-89-3 cis-5-hydroxy-2,2-dimethylcyclohexanecarbonitrile 
• 92945-38-5 aethyl(2,2-dimethyl-5-oxocyclohexyl)keton 
• 294618-81-8 3-[(benzyloxycarbonyl)amino]-4,4-dimethylcyclohexanone 
• 294618-82-9 5-[(benzyloxycarbonyl)amino]-4,4-dimethylaminocyclohex-2-en-1-one 
• 623563-89-3 3-Cyano-4,4-dimethylcyclohexanol 

Relevant academic research and scientific papers

Synthesis of dimeric and tetrameric macrolactams with cytotoxic activity

Cyclization of amino acid 14, in turn prepared from 4,4-dimethylcyclohex-2-en-1-one by standard chemistry, yielded the dimeric and tetrameric macrolactams 15 and 16, respectively, representing the first examples of 'taxoid-like' compounds with heterocycli

Formaldehyde dialkylhydrazones as neutral formyl anion and cyanide equivalents: Nucleophilic addition to conjugated enones

A versatile methodology for the nucleophihc formylation and cyanation of conjugated enones is reported. The procedure is based on the use of formaldehyde dimethylhydrazone, which, acting as a neutral formyl anion equivalent, adds to preformed trialkylsilyl-enone complexes. Both 4-(silyl- oxy)-3-enal hydrazones 3 or deprotected 4-oxo aldehyde monohydrazones 4 can be obtained at products depending on quenching conditions. In full analogy, an asymmetric version of the reaction using chiral formaldehyde SAMP- hydrazone as a neutral synthon of the chiral formyl anion has been developed, giving rise to the corresponding adducts 5 and 6 in good yields and with excellent diastereoselectivities (de 85-≤98%). Ozonolysis or HCl-mediated hydrolysis of adducts 4 and 6 readily affords racemic and optically enriched 4-oxo aldehydes 7, respectively. Additionally, high-yielding MMPP-oxidative cleavage of 4-oxo hydrazones 4 and 6 has been performed to obtain 4-oxo nitriles 8 in racemic and optically enriched forms, respectively. In this way, interesting chiral bifunctional building blocks, some of them bearing newly created stereogenic quaternary centers, have been efficiently synthesized.

New Chiral Dopants with an Optically Active Six-membered Ring for Ferroelectric Liquid Crystals. Effect of Direction of the Dipole Moment on Spontaneous Polarization

New chiral dopants containing an optically active six-membered ring with a cyano group were synthesized.New chiral dopants containing an optically active six-membered ring with an epoxy group were also synthesized and the effect of the direction of the di