56836-94-3Relevant academic research and scientific papers
Environment-friendly non-toxic synthesis method of clenbuterol hydrochloride
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Paragraph 0032; 0050-0053, (2020/07/21)
The invention provides an environment-friendly non-toxic synthesis method of clenbuterol hydrochloride. The synthesis method comprises the following steps: 1) preparing an intermediate 1; 2) preparingan intermediate 2; 3) preparing clenbuterol; and 4) preparing the clenbuterol hydrochloride. The synthesis method comprises the following steps: synthesizing an intermediate 1 by adopting an oxidation method; and then forming a Schiff base intermediate 2 with tert-butylamine, and then preparing clenbuterol by reduction so that the condition that an alpha-bromo-structure intermediate with genotoxicity is prepared by using liquid bromine or other brominating agents in a traditional production process is avoided, the new synthesis method is environment-friendly and non-toxic, and the clinical use risk of clenbuterol hydrochloride is effectively reduced.
Heteroarylethanol-pyridylalkylamines for controlling animal growth
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, (2008/06/13)
A compound for promoting livestock production and for controlling obesity in humans and animals, of the formula STR1 in which A represents =CH-- or =N--, R0 represents hydrogen or methyl, R1 and R3 each independently represents hydrogen, hydroxyl, halogen, cyano, alkyl, halogenoalkyl, hydroxyalkyl, alkoxycarbonyl, aminocarbonyl, mono- and dialkylaminocarbonyl, alkoxy, halogenoalkoxy, halogenoalkylthio, NHSO2 -alkyl, R2 represents hydrogen, hydroxyl, alkoxy or the radical --NR5 R6, R4 represents hydrogen, C1 -C10 -alkyl which is optionally substituted by hydroxyl, halogen, alkoxy, acyloxy or the radical --NH7 R8, or represents the radical COR9 or the radical --O--Z--R10, Z represents C1 -C10 -alkylene, -alkenylene or alkynylene, R5 represents hydrogen or alkyl, R6 represents hydrogen, alkyl, halogenoalkyl or acyl, or R5 and R6 together with the adjoining N atom form a saturated or unsaturated heterocyclic 4-, 5- or 6-membered ring, R7 and R8 each independently represents hydrogen, optionally substituted alkyl, optionally substituted aryl, R9 represents hydroxyl, alkoxy or the radical --NR7 R8, R10 represents hydroxyl, alkoxy, acyloxy, optionally substituted aryloxy or aralkyloxy, with the substituent R4 and the alkylamino group in the pyridyl ring of the formula I being in the p position with respect to one another, or a physiologically tolerated salt thereof, or, if A represents nitrogen, optionally the N-oxide thereof.
Secondary amines, their preparation and use in pharmaceutical compositions
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, (2008/06/13)
The compounds of the formula (II): STR1 and their pharmaceutically acceptable salts wherein R1 is a hydrogen, fluorine or chlorine atom or a hydroxyl, hydroxymethyl, methyl, methoxyl, amino, formamido, acetamido, methylsulphonylamido, nitro, benzyloxy, methylsulphonylmethyl, ureido, trifluoromethyl or p-methoxybenzylamino group; R2 is a hydrogen, fluorine or chlorine atom or a hydroxyl group; R3 is a hydrogen or chlorine atom or a hydroxyl group; R4 is a carboxylic acid group or a salt, ester or amide thereof; R5 is a hydrogen, chlorine or fluorine atom or a methyl, methoxyl or hydroxyl group or a carboxylic acid group or a salt, ester or amide thereof; R6 is a hydrogen atom or a methyl, or propyl group; X is an oxygen atom or a bond; and Y is an alkylene group of up to 6 carbon atoms or a bond have been found to possess anti-obesity and/or antihyperglycaemic activity.
1-Phenyl-2-aminoethanol derivatives
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, (2008/06/13)
The invention concerns compounds of the formula:- R1.CH(OH).CH2 NH.CR2 R3.A1. NH.CO.CHR4.A2.NR5. Q I wherein R1 is 3,4-bis[(3-8C)alkanoyloxy]-phenyl, 3,5- b
1-Phenyl-2-aminoethanol derivatives
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, (2008/06/13)
The invention concerns new topical anti-inflammatory 1-phenyl-2-aminoethanol derivatives of the general formula: wherein R1 is a phenyl bearing specific combinations of (2-12C)alkanoyloxy,[(2-12C)alkanoyloxy]methyl,chloro and amino substituents
