5685-06-3

Basic information

• Product Name: 4-methylthiazole-2(3H)-thione
• Synonyms: 4-methylthiazole-2(3H)-thione;4-Methyl-4-thiazoline-2-thione;2(3H)-Thiazolethione, 4-methyl-;4-Methyl-2(3H)-thiazolethione;4-Methyl-2-mercaptothiazole;4-Methyl-2-thiazolethiol;4-Methylthiazoline-2-thione;4-Thiazoline-2-thione, 4-methyl-
• CAS NO: 5685-06-3
• Molecular Formula: C₄H₅NS₂
• Molecular Weight: 131.2192
• EINECS: 227-152-2
• Mol File: 5685-06-3.mol
• Article Data: 15

Chemical Properties

• Melting Point: 89.3°C
• Boiling Point: 203.4 °C at 760 mmHg
• Flash Point: 76.8 °C
• Appearance: /solid
• Density: 1.263 (estimate)
• Vapor Pressure: 0.278mmHg at 25°C
• Refractive Index: 1.5000 (estimate)
• PKA: 8?+-.0.40(Predicted)
• CAS DataBase Reference: 4-methylthiazole-2(3H)-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methylthiazole-2(3H)-thione(5685-06-3)
• EPA Substance Registry System: 4-methylthiazole-2(3H)-thione(5685-06-3)

Safety Data

• Hazardous Substances Data: 5685-06-3(Hazardous Substances Data)

Usage

General Description

4-Methylthiazole-2(3H)-thione, also known as 4-methyl-2-thiazolthione, is a heterocyclic organic compound with the molecular formula C4H5NS. It is a yellow-orange solid with a slightly sulfurous odor, and it is considered to be a thione, which is a sulfur analog of a ketone. 4-Methylthiazole-2(3H)-thione is commonly used in the synthesis of pharmaceuticals, dyes, and pesticides. It has also been studied for its potential biological activities, including its antimicrobial and anticancer properties. Additionally, it has been investigated as a potential precursor to flavor and fragrance compounds. Overall, 4-Methylthiazole-2(3H)-thione is a versatile chemical with a range of potential applications in various industries.

InChI:InChI=1/C4H5NS2/c1-3-2-7-4(6)5-3/h2H,1H3,(H,5,6)

Upstream product

• 513-74-6 ammonium dithiocarbamate 
• 78-95-5 chloroacetone 
• 23826-98-4 bis(4-methylthiazol-2-yl) disulfide 
• 693-95-8 4-Methylthiazole 
• 60-29-7 diethyl ether 
• 64-17-5 ethanol 
• 110907-36-3 4-Methyl-2-phenyldisulfanyl-thiazole 
• 598-31-2 1-bromoacetone 
• 57658-34-1 2-mercapto-4-methylthiazole-5-carboxylic acid 
• 89861-47-2 4-methyl-3-[(1-oxohexadecyl)oxy]-2(3H)-thiazolethione 
• 1095-04-1 triphenyl thiophosphite 
• 100780-08-3 3-(3,3-diphenylpropionoxy-)-4-methylthiazole-2(3H)-thione 
• 152732-30-4 (2S,3R)-3-(3-Cyano-indol-1-ylmethyl)-oxirane-2-carboxylic acid 4-methyl-2-thioxo-thiazol-3-yl ester 
• 147727-23-9 C₁₅H₁₄N₂O₂ 

Downstream Products

• 5316-68-7 2-ethylsulfanyl-4-methyl-thiazole 
• 5316-72-3 2-(benzylthio)-4-methylthiazole 
• 5685-17-6 (4-Methyl-thiazol-2-ylmercapto)-essigsaeure 
• 55578-40-0 2-(4-methyl-thiazol-2-ylmercapto)-hydroquinone 
• 693-95-8 4-Methylthiazole 
• 113411-23-7 4-methylthiazole-2-sulfonamide 
• 23826-98-4 bis(4-methylthiazol-2-yl) disulfide 
• 71371-10-3 3-oxo-5-methyl-2-phenyl-2,3-dihydro-thiazolo[2,3-b]thiazolylium betaine 
• 16914-21-9 3-benzyl-2-benzylsulfanyl-4-methyl-thiazolium; bromide 
• 55379-29-8 2-benzoylsulfanyl-4-methyl-thiazole 
• 55379-12-9 4-methyl-2-(4-nitro-benzylsulfanyl)-thiazole 
• 93284-11-8 4-methyl-2-((2-nitrophenyl)disulfanyl)thiazole 
• 2591-05-1 2-(4-methyl-thiazol-2-ylsulfanyl)-1-phenyl-ethanone 
• 90356-75-5 4-nitro-3-trifluoromethyl-N-[2-hydroxy-2-methyl-3-(4-methylthiazol-2-ylthio)propionyl]aniline 

Relevant articles and documents

Synthesis of novel azabicyclo derivatives containing a thiazole moiety and their biological activity against pine-wood nematodes

To explore a new skeleton with nematicidal activity, a series of novel azabicyclo derivatives containing a thiazole moiety were designed, synthesized and evaluated for their nematicidal activities. The bioassay results against pine-wood nematodes (Bursaphelenchus xylophilus) showed that most of the title compounds displayed nematicidal activity at a concentration of 40 mg/L. Especially, the title compounds2-((8-methyl-8-azabicyclo[3.2.1]octan-3-yl)oxy)-4-(4-chlorophenyl)thiazole (7e), 2-((8-methyl-8-azabicyclo[3.2.1]octan-3-yl)thio)-4-phenylthiazole (10a) and 2-((8-methyl-8-azabicyclo [3.2.1]octan-3-yl)thio)-4-(4-chlorophenyl)thiazole (10e) exhibited more than 90% mortality against Bursaphelenchus xylophilus.

A process for the preparation method of thiabendazole

The invention relates to a new method for synthesizing thiabendazole. Acetone and chlorine are taken as starting materials to synthesize chloroacetone, chloroacetone not subjected to separation can directly react with thiocarbamide to obtain 2-Amino-4-methylthiazole which is subjected to diazotization to obtain 4-methylthiazole, and 4-methylthiazole is oxidized to produce 4-thiazolecarboxylic acid, and finally, 4-thiazolecarboxylic acid reacts with o-phenylenediamine to obtain the target object thiabendazole. The thiabendazole is a broad-spectrum anthelmintic, can repel roundworms, hookworms, whipworms, pinworms, strongyloises stercoralis and trichinization, is also a broad-spectrum efficient disinfectant and is widely used as a fruit fresh-keeping agent and a bactericidal mildew inhibitor in various fields over the past decade in China.

QUINAZOLINE DERIVATIVES AS TAM FAMILY KINASE INHIBITORS

Disclosed are compounds, compositions and methods for treating diseases, syndromes, conditions and disorders that are affected by the modulation of the activity of, e.g., the inhibition of, one or more members of the TAM family kinases.