568584-34-9

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Imidazolidinedione, 5-(4-fluorophenyl)is used as a potential candidate for the development of new drugs due to its anti-inflammatory, analgesic, or anticonvulsant properties. Its unique structure with a 4-fluorophenyl group may contribute to improved efficacy and selectivity in treating various conditions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2,4-Imidazolidinedione, 5-(4-fluorophenyl)is used for the synthesis of novel compounds with potentially improved biological activities. Its structural modifications can lead to the discovery of new drugs with better pharmacokinetic and pharmacodynamic profiles.

Upstream product

• 506-87-6 ammonium carbonate 
• 459-57-4 4-fluorobenzaldehyde 
• 124-38-9 carbon dioxide 
• 56464-70-1 2-amino-2-(4-fluorophenyl)acetonitrile 
• 140-75-0 para-fluorobenzylamine 
• 133721-87-6 2-(4-fluorophenyl)-2-hydroxyacetonitrile 

Relevant academic research and scientific papers

Method for continuously and quickly preparing DL-phenylglycine and analogue thereof

The invention provides a method for continuously and quickly preparing DL-phenylglycine and an analogue thereof. The method comprises the steps of adding 2-hydroxyl-phenylacetonitrile and an analoguethereof (cyanohydrin for short) and an aqueous ammonium bicarbonate solution into a microchannel reactor for a reaction, controlling the reaction temperature to be 80-130 DEG C, and controlling the reaction pressure to be 0.5-2.0 MPa, wherein the standing time of the reactants in a microchannel is 1-8 min, and an aqueous solution of 5-phenyl-hydantoin and an analogue thereof (hydantoin for short)is obtained; adding the hydantoin and alkali into the microchannel reactor for a reaction, controlling the reaction temperature to be 120-200 DEG C, and controlling the reaction pressure to be 1.0-3.5MPa, wherein the standing time of the reactants in the microchannel is 1-8 min, and then a saline solution of phenylglycine and an analogue thereof is obtained; conducting acidification neutralization and crystallization to obtain the phenylglycine and the analogue thereof. According to the method, the microchannel reactor is adopted, the reaction time is greatly shorted, the reaction speed is increased, pyrolysis and polymerization of the cyanohydrin are reduced, no by-products are generated, the products are high in yield, clean and environmentally friendly, and the production cost is lowered.

A Sustainable, Semi-Continuous Flow Synthesis of Hydantoins

Hydantoins are an important class of heterocycles with applications in pharmacy, agriculture, and as intermediates in organic synthesis. Traditional synthetic procedures to access hydantoins are target oriented with multiple synthetic steps and often use reagents that are not commercially available or sustainable. Herein, an efficient process is described for accessing hydantoins starting from commercially available amines using consecutive gas–liquid transformations (oxygen, carbon dioxide). This semi-continuous process produced ten benzylic/aliphatic hydantoins in good overall yields (52–84 %).

Ruthenium catalyzed hydroaminoalkylation of isoprene via transfer hydrogenation: Byproduct-free prenylation of hydantoins

The ruthenium catalyst derived from Ru3(CO)12 and triphos [Ph2P(CH2CH2PPh2) 2] promotes the direct C-C coupling of isoprene with aryl substituted hydantoins 1a-1f at the diene C4-position to furnish products of n-prenylation 2a-2f. A mechanism involving hydantoin dehydrogenation followed by diene-imine oxidative coupling to furnish a transient aza-ruthencyclopentene is proposed.