56862-34-1

Basic information

• Product Name: (1-PHENYL-ETHYL)-PROP-2-YNYL-AMINE
• Synonyms: (1-PHENYL-ETHYL)-PROP-2-YNYL-AMINE;TIMTEC-BB SBB010417;N-(1-Phenylethyl)prop-2-yn-1-amine
• CAS NO: 56862-34-1
• Molecular Formula: C₁₁H₁₃N
• Molecular Weight: 159.23
• Mol File: 56862-34-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: (1-PHENYL-ETHYL)-PROP-2-YNYL-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (1-PHENYL-ETHYL)-PROP-2-YNYL-AMINE(56862-34-1)
• EPA Substance Registry System: (1-PHENYL-ETHYL)-PROP-2-YNYL-AMINE(56862-34-1)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 56862-34-1(Hazardous Substances Data)

Usage

General Description

(1-Phenyl-ethyl)-prop-2-ynyl-amine is a chemical compound with the molecular formula C11H11N. It is a propargylamine derivative, meaning it contains a propargyl group (C≡C-CH2-) attached to an amine group (NH2). (1-PHENYL-ETHYL)-PROP-2-YNYL-AMINE is commonly used in the pharmaceutical industry for the synthesis of various drugs and in organic chemistry as a reagent for creating new compounds. Its unique structure and properties make it useful in the development of potential therapeutic agents and in the study of organic reactions involving propargylamines. Additionally, it is important to handle this compound with caution and in accordance with appropriate safety protocols, as with all chemical substances.

Upstream product

• 106-96-7 propargyl bromide 
• 618-36-0 rac-methylbenzylamine 

Downstream Products

• 951128-39-5 N-tert-butoxycarbonyl-N-(1-phenylethyl)-N-(prop-2-yn-1-yl)amine 
• 149529-74-8 N-(α-methylbenzyl)pentylamine 
• 1070-75-3 dilithium acetylide 
• 14630-40-1 Bis(trimethylsilyl)ethyne 
• 3193-62-2 N-benzyl-1-phenylethylamine 
• 880073-68-7 N-(α-methylbenzyl)(5-methylthiophen-2-yl)methylamine 
• 161119-98-8 (RS)-N-(furan-2-ylmethyl)-N-(α-methylbenzyl)amine 
• 2881-62-1 disodium acetylide 
• 1041425-05-1 N-(1-phenylethyl)-N-(2-propynyl)-2-chloroacetamide 
• 618-36-0 rac-methylbenzylamine 

Relevant articles and documents

Controllable encapsulation of silver nanoparticles by porous pyridine-based covalent organic frameworks for efficient CO2conversion using propargylic amines

The conversion of CO2 into value-added chemicals is an attractive alternative to produce valuable fuels and chemicals. In this work, we demonstrate two pyridine-based covalent organic frameworks (COFs) with rich porosity for the size-controlled synthesis

Highly Efficient Conversion of Propargylic Amines and CO2 Catalyzed by Noble-Metal-Free [Zn116] Nanocages

The reaction of propargylic amines and CO2 can provide high-value-added chemical products. However, most of catalysts in such reactions employ noble metals to obtain high yield, and it is important to seek eco-friendly noble-metal-free MOFs catalysts. Here, a giant and lantern-like [Zn116] nanocage in zinc-tetrazole 3D framework [Zn22(Trz)8(OH)12(H2O)9?8 H2O]n Trz=(C4N12O)4? (1) was obtained and structurally characterized. It consists of six [Zn14O21] clusters and eight [Zn4O4] clusters. To our knowledge, this is the highest-nuclearity nanocages constructed by Zn-clusters as building blocks to date. Importantly, catalytic investigations reveal that 1 can efficiently catalyze the cycloaddition of propargylic amines with CO2, exclusively affording various 2-oxazolidinones under mild conditions. It is the first eco-friendly noble-metal-free MOFs catalyst for the cyclization of propargylic amines with CO2. DFT calculations uncover that ZnII ions can efficiently activate both C≡C bonds of propargylic amines and CO2 by coordination interaction. NMR and FTIR spectroscopy further prove that Zn-clusters play an important role in activating C≡C bonds of propargylic amines. Furthermore, the electronic properties of related reactants, intermediates and products can help to understand the basic reaction mechanism and crucial role of catalyst 1.

Metal Acetylide Elimination: The Key Step in the Cascade Decomposition and Transformation of Metalated Propargylamines

Metal acetylide elimination facilitates a novel one-pot cascade metalation and elimination/addition route to a series of unsymmetrical secondary amines from the reaction of secondary propargylamines with organometallic reagents. Spectroscopic evidence suggests a dimetalated amido intermediate rather than an allene.