56865-31-7Relevant academic research and scientific papers
Synthesis of tetrasaccharides as possible metastatic inhibitors
Zhu, Xiao Xiang,Ding, Ping Yu,Cai, Meng Shen
, p. 229 - 235 (1996)
The synthesis is reported of the possible metastatic inhibitors - methyl β-D-galactopyranosyl-(1 → 4)-(2-acetamido-2-deoxy-α-D-glucopyranosyl)-(1 → 6)-β-D-galactopyranosyl-(1 → 4)-β-D-glucopyranoside (11) and methyl β-D-galactopyranosyl-(1 → 4)-(2-acetami
An efficient glycosylation reaction for the synthesis of asialo GM2 analogues
Sun, Bin,Pukin, Aliaksei V.,Visser, Gerben M.,Zuilhof, Han
, p. 7371 - 7374 (2007/10/03)
We investigated the coupling reaction of glycosyl donors N-trichloroethoxycarbonyl-galactosamine-O-trichloroacetimidate (2a) and N-p-nitrobenzyloxycarbonyl-galactosamine-O-trichloroacetimidate (2b) with the 4′-OH of lactose derivatives (3a-d) to synthesiz
Synthesis and biological evaluation of sialylmimetics as rotavirus inhibitors
Fazli,Bradley,Kiefel,Jolly,Holmes,Von Itzstein
, p. 3292 - 3301 (2007/10/03)
Rotaviruses cause severe gastroenteritis in infants and are estimated to be responsible for over 600 000 deaths annually, primarily in developing countries. The development of potential inhibitors of this virus is therefore of great interest, particularly since the safety and efficacy of rotaviral vaccines has recently been questioned. This study describes the synthesis of a variety of compounds that can be considered as mimetics of N-acetylneuraminic acid thioglycosides and the subsequent in vitro biological evaluation of these sialylmimetics as inhibitors of rotaviral infection. Our results show that readily accessible carbohydrate-based compounds have the potential to act as inhibitors of rotaviral replication in vitro, presumably through inhibition of the rotaviral adhesion process.
Carbohydrate-derived Surfactents: Synthesis and Phase Behaviour of Methyl 4',6'-Di-O-alkyl-β-lactosides
Langlois, Virginie,Williams, J. Michael
, p. 2103 - 2106 (2007/10/02)
In order to study the physical properties of lactose-derived surfactants, methyl 4',6'-di-O-hexyl-β-lactoside and methyl 4',6'-di-O-octyl-β-lactoside were prepared.The 4',6'-O-isopropylidene ketal was used as a temporary protecting group in the key interm
