56877-60-2Relevant academic research and scientific papers
Inhibition of DNA topoisomerase II by azaelliptitoxins functionalized in the variable substituent domain
Tepe, Jetze J.,Madalengoitia, Jose S.,Slunt, Kelli M.,Werbovetz, Karl W.,Spoors, P. Grant,Macdonald, Timothy L.
, p. 2188 - 2196 (1996)
A series of novel C11-substituted derivatives of azaelliptitoxin (azatoxin) have been synthesized and tested for their inhibitory activity against human DNA topoisomerase II. Incorporation of a C11 polyamine or amine resulted in an i
