56882-77-0Relevant academic research and scientific papers
Novel 1,3,4-thiadiazole conjugates derived from protocatechuic acid: Synthesis, antioxidant activity, and computational and electrochemical studies
Jakovljevi?, Katarina,Joksovi?, Milan D.,Botta, Bruno,Jovanovi?, Ljiljana S.,Avdovi?, Edina,Markovi?, Zoran,Mihailovi?, Vladimir,Andri?, Marijana,Trifunovi?, Sne?ana,Markovi?, Violeta
, p. 585 - 598 (2019/07/05)
A series of 15 novel 1,3,4-thiadiazole amide derivatives containing a protocatechuic acid moiety were synthesized and structurally characterized. In addition, the corresponding imino (4) and amino (5) analogues of a phenyl-substituted 1,3,4-thiadiazole am
PhI-Catalyzed Intramolecular Oxidative Coupling Toward Synthesis of 2-Amino-1,3,4-Thiadizoles
Han, Yingzhi,Sun, Yadong,Abdukader, Ablimit,Liu, Bifu,Wang, Duozhi
, p. 3486 - 3491 (2018/09/27)
A highly efficient method for the synthesis of thiadiazole derivatives via intramolecular oxidative coupling of thiosemicarbazide, using the in situ generated hypervalent iodine(III) reagents is developed. The protocol can be carried out smoothly and provides a variety of thiadiazole derivatives in moderate to excellent yields. Graphical Abstract: A highly efficient method for the synthesis of thiadiazole derivatives via PhI-catalyzed intramolecular oxidative coupling of thiosemicarbazide has been developed.
Synthesis and evaluation of novel 1,3,4-thiadiazole–fluoroquinolone hybrids as antibacterial, antituberculosis, and anticancer agents
Demirci, Asl?,Karayel, Kaan G?k?e,Tatar, Esra,Okullu, Sinem ?KTEM,Unübol, Nihan,Ta?li, Pakize Neslihan,Kocag?z, Zühtü Tan?l,Sahin, Fikrettin,Kü?ükgüzel, Ilkay
, p. 839 - 858 (2018/06/07)
A series of 5-substituted-1,3,4-thiadiazole-based fluoroquinolone derivatives were designed as potential antibacterial and anticancer agents using a molecular hybridization approach. The target compounds 16–25 were synthesized by reacting the correspondin
IL-8 RECEPTOR ANTAGONISTS
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Page/Page column 25, (2008/12/06)
This invention relates to novel compounds, compositions and combinations thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
Thiadiazole derivatives active on the central nervous system and pharmaceutical compositions
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, (2008/06/13)
The invention relates to thiadiazole derivatives corresponding to the formula: STR1 in which R represents: a linear or branched alkyl group having from 1 to 5 carbon atoms; a cycloalkyl group having 5 or 6 carbon atoms; a phenyl group optionally substitut
