56895-13-7

Usage

Physical state

Colorless to pale yellow liquid

Odor

Pungent

Reactivity

Highly reactive with water and alcohols

Usage

Reagent for the preparation of various pharmaceuticals and agrochemicals

Potential

Intermediate in the production of various chemicals

Hazardous nature

Handle with care

Upstream product

• 371-41-5 4-Fluorophenol 
• 2967-70-6 2-(p-fluorophenoxy)propionic acid 

Downstream Products

• 63650-17-9 2-(p-fluorophenoxy)-1-propanol 
• 1174133-49-3 1-[2-(4-fluorophenoxy)propanoyl]-3-(4-fluorophenyl)imidazolidine-2,4-dione 
• 1174133-50-6 3-(4-chlorophenyl)-1-[2-(4-fluorophenoxy)propanoyl]imidazolidine-2,4-dione 
• 1174133-48-2 1-[2-(4-fluorophenoxy)propanoyl]-3-phenylimidazolidine-2,4-dione 

Relevant academic research and scientific papers

Highly Enantioselective Hydrogenation of Amides via Dynamic Kinetic Resolution Under Low Pressure and Room Temperature

High-throughput screening and lab-scale optimization were combined to develop the catalytic system trans-RuCl2((S,S)-skewphos)((R,R)-dpen), 2-PrONa, and 2-PrOH. This system hydrogenates functionalized α-phenoxy and related amides at room temperature under 4 atm H2 pressure to give chiral alcohols with up to 99% yield and in greater than 99% enantiomeric excess via dynamic kinetic resolution.

Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 2. 2-Phenoxy-, 2-(phenylthio)-, and 2-(phenylamino)alkanoic acid esters

Further modifications of the leads ((R)-(+)-hyoscyamine and (p- chlorophenyl)propionic acid α-tropanyl ester), which show analgesic and nootropic activities as a consequence of increased central presynaptic ACh release, are reported. 2-Phenoxy- and 2-(phenylthio)alkanoic acid esters showed the best results. Several members of these classes possess analgesic properties which are comparable to that of morphine and at the same time are able to reverse dicyclomine-induced amnesia. Confirmation was found that the mechanism of action is due to an increase in ACh release at central muscarinic synapses and that both auto- and heteroreceptors controlling ACh release are very likely involved. According to the results obtained with (R)- (+)-hyoscyamine, analgesic activity is stereochemistry dependent, since the R-(+)-enantiomers are always more efficacious than the corresponding S-(-)- ones. On the basis of their potency and acute toxicity, compounds (±)-28 (SM21) and (±)-42 (SM32) were selected for further study.