63650-17-9Relevant academic research and scientific papers
Highly Enantioselective Hydrogenation of Amides via Dynamic Kinetic Resolution Under Low Pressure and Room Temperature
Rasu, Loorthuraja,John, Jeremy M.,Stephenson, Elanna,Endean, Riley,Kalapugama, Suneth,Clément, Roxanne,Bergens, Steven H.
, p. 3065 - 3071 (2017/03/11)
High-throughput screening and lab-scale optimization were combined to develop the catalytic system trans-RuCl2((S,S)-skewphos)((R,R)-dpen), 2-PrONa, and 2-PrOH. This system hydrogenates functionalized α-phenoxy and related amides at room temperature under 4 atm H2 pressure to give chiral alcohols with up to 99% yield and in greater than 99% enantiomeric excess via dynamic kinetic resolution.
Resolution of 2-aryloxy-1-propanols via lipase-catalyzed enantioselective acylation in organic media
Miyazawa, Toshifumi,Yukawa, Tomoyuki,Koshiba, Takashi,Sakamoto, Hiroko,Ueji, Shinichi,Yanagihara, Ryoji,Yamada, Takashi
, p. 1595 - 1602 (2007/10/03)
2-Aryloxy-1-propanols, primary alcohols with an oxygen atom at the stereocenter, were resolved with good to high enantioselectivity by acylation with vinyl butanoate mediated by Pseudomonas sp. lipase in di-iso-propyl ether. Potential factors affecting the enantioselectivity of the enzymatic acylation were examined: solvents, acyl donors and temperature. Using this enantioselective acylation procedure, enantiomerically pure (R)-2-(4-chlorophenoxy)-1-propanol was prepared on a gram scale.
Method of treating lipidemia with aryloxyalkylaminobenzoic acids and esters
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, (2008/06/13)
Aryloxyalkylaminobenzoic acids and esters as hypolipemic compounds.
Phenoxyalkanol derivatives
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, (2008/06/13)
Phenoxylakanols of the formula STR1 wherein R1 is H or CH3 ; R2 is CH3 or C6 H5 ; R3 is 4-Hal-phenoxymethyl, 1,2,3,4-tetrahydro-1-naphthyl, 1-pyrryl, piperidino, isoindoline, 1,2
