56907-26-7Relevant articles and documents
Synthesis of γ,γ-Disubstituted Butenolides through a Doubly Vinylogous Organocatalytic Cycloaddition
Skrzyńska, Anna,Drelich, Piotr,Frankowski, Sebastian,Albrecht, ?ukasz
supporting information, p. 16543 - 16547 (2018/10/26)
A novel organocatalytic approach to γ,γ-disubstituted butenolides is described. It is based on a fully site-selective functionalization of 5-alkylidenefuran-2(5H)-ones via trienamine-mediated [4+2]-cycloaddition with α,β,γ,δ-diunsaturated aldehydes. The developed methodology proceeds with excellent stereocontrol and constitutes a unique example of trienamine chemistry with vinylogous dienophiles. Importantly, the reaction has very broad scope and allows for the introduction of substituents also in the α- or the β-position of the butenolide ring. Usefulness of the products obtained has been confirmed in the intramolecular Stetter reaction leading to polycyclic product.
Synthesis of polyconjugated aldehydes using a new Horner--Wadsworth--Emmons reagent.
Rein,Akermark,Helquist
, p. 569 - 572 (2007/10/02)
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