56915-84-5

Usage

Type of compound

Ketone derivative

Phenyl ring

Substituted with an amino group, a pyrrolidinyl group, and an ethanone group

Amino group

Attached to the 2nd position of the phenyl ring

Pyrrolidinyl group

Attached to the 5th position of the phenyl ring

Ethanone group

Attached to the 1st position of the phenyl ring

Field of application

Organic chemistry

Synthetic reactions

Utilized in various synthetic reactions in organic chemistry

Pharmaceutical research

Potential applications in pharmaceutical research and drug discovery

Biological activity

Presence of amino and pyrrolidinyl groups suggests potential biological activity

Building block

Could be used as a building block in the synthesis of various bioactive molecules

Upstream product

• 18640-60-3 5-chloro-2-nitroacetophenone 
• 56915-83-4 2'-nitro-5'-(1-pyrrolidinyl)acetophenone 

Downstream Products

• 1025924-50-8 N-(2-Acetyl-4-pyrrolidin-1-yl-phenyl)-3-methoxy-benzamide 
• 1026572-12-2 N-(2-Acetyl-4-pyrrolidin-1-yl-phenyl)-3-trifluoromethoxy-benzamide 
• 377740-13-1 N-(2-acetyl-4-pyrrolidin-1-yl-phenyl)-2-fluoro-benzamide 
• 1452587-54-0 N-(2-acetyl-4-(pyrrolidin-1-yl)phenyl)-3,5-bis(benzyloxy)benzamide 
• 1452587-55-1 N-(2-a cetyl-4-(pyrrolidin-1-yl)phenyl)-3-(benzyloxy)-5-methoxybenzamide 
• 1452587-56-2 N-(2-acetyl-4-(pyrrolidin-1-yl)phenyl)-3-(benzyloxy)-5-ethoxybenzamide 
• 1421446-97-0 N-(2-acetyl-4-(pyrrolidin-1-yl)phenyl)-3-nitrobenzamide 
• 1421446-95-8 C₂₁H₂₃N₃O 
• 1421447-00-8 N-(2-acetyl-4-(pyrrolidin-1-yl)phenyl)-3-(ethylamino)benzamide 
• 1421446-98-1 N-(2-acetyl-4-(pyrrolidin-1-yl)phenyl)-3-aminobenzamide 

Relevant academic research and scientific papers

SYNTHESIS AND ANTICANCER ACTIVITY OF ARYL AND HETEROARYL-QUINOLIN DERIVATIVES

A compound of Formula I is disclosed as follows: or a pharmaceutically acceptable salt, prodrug, solvate, or metabolite thereof, wherein R is hydrogen, P(═O)(OH)2, P(═O)(O(C1-C18)alkylene(C6-C20)aryl)2, P(═O)(OH)(OM), P(═O)(OM)2, P═O(O2M), S(═O)(OH)2, S(═O)(O(C1-C18)alkylene(C6-C20)aryl)2, S(═O)(OH)(OM), S(═O)(OM)2; M is a monovalent or divalent metal ion, or alkylammonium ion; W is (C6-C20)aryl, (C6-C20)heteroaryl, (C1-C18)alkyl(C6-C20)aryl, (C1-C18)alkyl(C6-C20)heteroaryl, hydroxy(C6-C20)aryl, hydroxy(C6-C20)heteroaryl, (C1-C18)alkoxy(C6-C20)aryl, (C1-C18)alkoxy(C6-C20)heteroaryl, (C1-C18)alkylenedioxy(C6-C20)aryl, (C1-C18)alkylenedioxy(C6-C20)heteroaryl, halo(C6-C20)aryl, halo(C6-C20)heteroaryl, (C1-C18)alkylamino(C6-C20)aryl, (C1-C18)alkylamino(C6-C20)heteroaryl, (C1-C18)cycloalkylamino(C6-C20)aryl, or (C1-C18)cycloalkylamino(C6-C20)heteroaryl, and their OR8 substutes; R5 is (C1-C18alkoxy, hydrogen, hydroxyl, O—(C1-C18)alkyl(C6-C20)aryl, halo or OR8, or R5 and R6 are (C1-C18)dioxy provided that R7 is hydrogen; R6 is hydroxyl, O—(C1-C18)alkyl(C6-C20)aryl, halo or ORR, (C1-C18)alkoxy, (C1-C18)alkylamino, or (C1-C18)cycloalkylamino, or R6 and R7 are (C1-C18)dioxy provided that R5 is hydrogen; R7 is hydrogen, halo or OR8, hydroxyl, or O—(C1-C18)alkyl(C6-C20)aryl; and R8 is P(═O)(OH)2, P(═O)(O(C1-C18)alkyl(C6-C20)aryl)2, P(═O)(OH)(OM), or P(═O)(OM)2, P═O(O2M).

Antitumor agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents

Fluorinated 2-phenyl-4-quinolone derivatives were synthesized and evaluated in National Cancer Institute's 60 human tumor cell line in vitro screen. From the results, the ketone moiety plays an essential role in activity. Among the compounds tested, 2′-fl

Antitumor Agents. 155. Synthesis and Biological Evaluation of 3',6,7-Substituted 2-Phenyl-4-quinolones as Antimicrotubule Agents

A series of 3',6,7-substituted 2-phenyl-4-quinolones were designed and synthesized as antimitotic antitumor agents. All compounds showed cytotoxic effects (log GI50/=-4.0; log drug molar concentration required to cause 50percent inhibition) against the growth of a variety of human tumor cell lines, including those derived from solid tumors such as non-small cell lung, colon, central nervous system, ovary, prostate, and breast cancers, when evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. The most potent compound (26) demonstrated strong cytotoxic effects with GI50 values in the nanomolar or subnanomolar range in almost all the tumor cell lines. Compound 26 was also a potent inhibitor of tubulin polymerization and radiolabeled colchicine binding to tubulin, with activity comparable to those of the potent antimitotic natural products colchicine, podophyllotoxin, and combretastatin A-4.