18640-60-3

Basic information

• Product Name: 1-(5-CHLORO-2-NITROPHENYL)-1-ETHANONE
• Synonyms: 1-(5-CHLORO-2-NITROPHENYL)-1-ETHANONE;5-Chloro-2-nitroacetophenone;1-(5-Chloro-2-nitrophenyl)ethanone;1-(5-Chloro-2-nitrophenyl)ethan-1-one;NSC 81223;1-(5-chloro-2-mitropenyl)ethanone
• CAS NO: 18640-60-3
• Molecular Formula: C₈H₆ClNO₃
• Molecular Weight: 199.59
• Mol File: 18640-60-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 58-61°C
• Boiling Point: 332.2 °C at 760 mmHg
• Flash Point: 154.7 °C
• Appearance: /
• Density: 1.378 g/cm³
• Vapor Pressure: 0.000148mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(5-CHLORO-2-NITROPHENYL)-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-CHLORO-2-NITROPHENYL)-1-ETHANONE(18640-60-3)
• EPA Substance Registry System: 1-(5-CHLORO-2-NITROPHENYL)-1-ETHANONE(18640-60-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 18640-60-3(Hazardous Substances Data)

Usage

General Description

1-(5-chloro-2-nitrophenyl)-1-ethanone is a chemical compound with the molecular formula C8H6ClNO3. It is a yellow crystalline solid with a molecular weight of 199.59 g/mol. 1-(5-CHLORO-2-NITROPHENYL)-1-ETHANONE is a derivative of acetophenone and contains a chlorine atom and a nitro group attached to the phenyl ring. It can be used as a reagent in organic synthesis and as an intermediate in the production of various pharmaceuticals and agrochemicals. The presence of the nitro and chlorine groups makes it a potential environmental and health hazard, and it should be handled with caution and proper protective equipment.

InChI:InChI=1/C8H6ClNO3/c1-5(11)7-4-6(9)2-3-8(7)10(12)13/h2-4H,1H3

Upstream product

• 99-02-5 3'-Chloroacetophenone 
• 16994-13-1 3-amino-6-nitroacetophenone 
• 6637-18-9 5-acetamido-2-nitroacetophenone 
• 7463-31-2 3-Acetamidoacetophenone 
• 41994-44-9 5-chloro-2-nitrobenzoyl chloride 
• 105-53-3 diethyl malonate 

Downstream Products

• 56915-83-4 2'-nitro-5'-(1-pyrrolidinyl)acetophenone 
• 1355235-17-4 N-(2-Acetyl-4-morpholinophenyl)-2-benzyloxybenzamide 
• 1355235-39-0 2-(2-benzyloxyphenyl)-6-morpholinoquinolin-4-one 
• 1355235-60-7 2-(2-hydroxyphenyl)-6-morpholinoquinolin-4-one 
• 33358-41-7 (5-chloro-2-nitro-phenyl)-phenyl sulfide 
• 100-00-5 4-chlorobenzonitrile 
• 1085705-79-8 2-(3-chloro-6-nitrophenyl)benzothiazole 
• 611-06-3 2,4-dichloronitrobenzene 
• 4104-35-2 5-chloro-3-methyl-benz[c]isoxazole 
• 81883-95-6 (5-chloro-2-nitrophenyl)(3-phenyloxiran-2-yl)methanone 
• 81883-85-4 (E)-1-(5-Chloro-2-nitro-phenyl)-3-phenyl-propenone 
• 1423715-33-6 (E)-N'-(1-(5-chloro-2-nitrophenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide 
• 1339009-98-1 2-(3-hydroxyphenyl)-3-benzyl-6-(morpholin-4-yl)-1,4-dihydroquinolin-4-one 

Relevant articles and documents

A 1H-indazole derivatives preparation method

The invention provides a method for preparing 3-methyl-5-R-1H-indazole easily, safely and efficiently without performing any hydrazine hydrate reflux heating reaction or purifying a product and making the product pass through a column. The method at least comprises the following steps of: a, performing a diazo-reaction on 2-amino-5-R-hypnone serving as a raw material or an intermediate under the condition of an acid solution to generate a diazo salt; b, slowly adding a stannous chloride-hydrate hydrochloric acid solution into the diazo salt obtained in the step a for reacting to generate a 3-methyl-5-R-1H-indazole solution; and c, cooling the solution obtained in the step b under the condition that the pH value is 8-9, and precipitating a product out, wherein R in the steps above represents H or a halogen element.

De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin- 4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors

Kinesin spindle protein (KSP) inhibitors are a promising class of anticancer agents that cause mitotic arrest in cells from a failure to form functional bipolar mitotic spindles. Here, we report the design, synthesis and biological evaluation of a novel series of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones using de novo design method. The synthesized compound was evaluated and proved to have potent inhibitory activities in the KSP ATPase. Compounds 15j and 15p show potent inhibitory activities in cell proliferation assays. Preferred compound 15j markedly induced G2/M phase cell cycle arrest with characteristic monoastral spindles and subsequent cell death in A549 cells. In vivo evaluation of 15j on the growth of transplantable S180 sarcoma in mice suggested its therapeutic potential for further development.

N-PHENYL-1,1,1-TRIFLUOROMETHANESULFONAMIDE HYDRAZONE DERIVATIVE COMPOUNDS AND THEIR USAGE IN CONTROLLING PARASITES

Novel N-phenyl-1,1,1-trifluoromethanesulfonamide compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo and ex vivo.