5692-35-3

Basic information

• Product Name: Benzamide, 3,5-dimethyl- (7CI,8CI,9CI)
• Synonyms: Benzamide, 3,5-dimethyl- (7CI,8CI,9CI);3,5-dimethylbenzamide
• CAS NO: 5692-35-3
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.18974
• Product Categories: AMIDE
• Mol File: 5692-35-3.mol
• Article Data: 22

Chemical Properties

• Melting Point: 135-135.5 °C(Solv: water (7732-18-5))
• Boiling Point: 231.8 °C at 760 mmHg
• Flash Point: 94 °C
• Appearance: /
• Density: 1.06 g/cm³
• Vapor Pressure: 0.061mmHg at 25°C
• Refractive Index: 1.55
• PKA: 16.22±0.50(Predicted)
• CAS DataBase Reference: Benzamide, 3,5-dimethyl- (7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 3,5-dimethyl- (7CI,8CI,9CI)(5692-35-3)
• EPA Substance Registry System: Benzamide, 3,5-dimethyl- (7CI,8CI,9CI)(5692-35-3)

Safety Data

• Hazardous Substances Data: 5692-35-3(Hazardous Substances Data)

Usage

General Description

Benzamide, 3,5-dimethyl- (7CI,8CI,9CI) is a chemical compound with the molecular formula C9H11NO. It is a derivative of benzamide and consists of a benzene ring with an amide group and two methyl groups attached at the 3 and 5 positions. This chemical is widely used in the pharmaceutical and chemical industries as a building block for the synthesis of various compounds. It is also utilized in organic synthesis and research as a reagent and intermediate. The properties and uses of benzamide, 3,5-dimethyl- make it a valuable and versatile compound in various applications.

InChI:InChI=1/C9H11NO/c1-6-3-7(2)5-8(4-6)9(10)11/h3-5H,1-2H3,(H2,10,11)

Upstream product

• 6613-44-1 3,5-dimethylbenzoyl chloride 
• 108-24-7 acetic anhydride 
• 72569-75-6 N-(2-pyridylmethyl)-3,5-dimethylbenzamide N-Oxide 
• 79988-88-8 N-<(α-hydroxy)-4-pyridylmethyl>-3,5-dimethylbenzamide 
• 108-67-8 1,3,5-trimethyl-benzene 
• 1202932-70-4 N-methoxy-3,5-dimethylbenzamide 
• 201230-82-2 carbon monoxide 
• 22445-41-6 3,5-dimethylphenyl iodide 
• 5779-95-3 3,5-dimethylbenzaldehyde 
• 108462-88-0 (E)-ethyl 2-cyano-3-(4-pyridyl)-3-(3,5-dimethylbenzoylamino)acrylate 
• 64-17-5 ethanol 
• 79988-86-6 N-<(α-acetoxy)-4-pyridylmethyl>-3,5-dimethylbenzamide 
• 22445-42-7 3,5-dimethylbenzonitrile 
• 556-96-7 5-bromo-1,3-xylene 

Downstream Products

• 22445-42-7 3,5-dimethylbenzonitrile 
• 108-69-0 3,5-dimethylaminoaniline 
• 78710-55-1 3,5-dimethylbenzyl amine 
• 13319-70-5 3,5-dimethylbenzophenone 
• 172369-18-5 N,3,5-trimethylbenzamide 
• 57312-28-4 C₁₁H₁₅NO 
• 124289-23-2 3-(bromomethyl)-5-methylbenzonitrile 

Relevant articles and documents

Mechanism of Acid-Catalyzed Proton Exchange in Amides

The kinetics of acid-catalyzed proton exchange in a series of primary amides were studied by NMR.The saturation-transfer method measures independently all six rate constants for exchange among sites HE, HZ, and solvent OH (usually et

Method for preparing primary and secondary amide compounds

The invention belongs to the field of organic chemical synthesis, and particularly relates to a method for preparing primary and secondary amide compounds. The method for preparing primary and secondary amide compounds comprises the following steps of carrying out catalytic reduction on an N-substituted amide compound at 30-130 DEG C by using a protic solvent as a reduction reagent and a dichloro(p-methyl isopropylbenzene) ruthenium (II) dimer complex as a catalyst to obtain a reaction solution after the reduction reaction is finished, and carrying out post-treatment on the reaction solution to obtain the corresponding primary amide compound or secondary amide compound. According to the method for preparing the primary and secondary amide compounds, the transfer hydrogenation reaction of nitrogen-oxygen and nitrogen-carbon bonds is realized, the reaction conditions are mild and simple, the substrate application range is wide, the operation is convenient, and the corresponding primary amide compound or secondary amide compound is obtained with high efficiency and high selectivity.

Supported palladium catalyzed aminocarbonylation of aryl iodides employing bench-stable CO and NH3surrogates

A simple, efficient and phosphine free protocol for carbonylative synthesis of primary aromatic amides under polystyrene supported palladium (Pd?PS) nanoparticle (NP) catalyzed conditions has been demonstrated. Herein, instead of using two toxic and difficult to handle gases simultaneously, we have employed the solid, economical, bench stable oxalic acid as the CO source and ammonium carbamate as the NH3source in a single pot reaction. For the first time, we have applied two non-gaseous surrogates simultaneously under heterogeneous catalyst (Pd?PS) conditions for the synthesis of primary amides using an easy to handle double-vial (DV) system. The developed strategy showed a good functional group tolerance towards a wide range of aryl iodides and afforded primary aromatic amides in good yields. The Pd?PS catalyst was easy to separate and can be recycled up to four consecutive runs with small loss in catalytic activity. We have successfully extended the scope of the methodology to the synthesis of isoindole-1,3-diones from 1,2-dihalobenzene, 2-halobenzoates and 2-halobenzoic acid following double and single carbonylative cyclization approaches.