56922-67-9

Upstream product

• 3256-38-0 (4-(hexyloxy)phenyl)methanol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 111-25-1 1-bromo-hexane 
• 5736-94-7 4-(hexyloxy)benzaldehyde 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 50822-54-3 methyl 4-hexyloxybenzoate 

Downstream Products

• 155929-62-7 3,4,5-Tris-(4-hexyloxy-benzyloxy)-benzoic acid methyl ester 
• 1372712-87-2 C₂₂H₂₆N₂O₂ 
• 141544-91-4 1,4-bis(4-hexyloxyphenyl)buta-1,3-diene 
• 155929-56-9 3,4,5-tris(p-hexyloxybenzyloxy)benzoic acid 

Relevant academic research and scientific papers

Structure-activity relationship (SAR) studies on the mutagenic properties of 2,7-diaminofluorene and 2,7-diaminocarbazole derivatives

We discovered that 2,7-diaminofluorene or 2,7-diaminocarbazole moiety can be employed as a core structure of highly effective NS5A inhibitors that are connected through amide bonds to proline-valine-carbamate motifs. Amide bonds can be easily cleaved via various metabolic pathways upon administration into the body, and metabolites containing 2,7-diaminofluorene and 2,7-diaminocarbazole core structures have been known to be strong mutagens. To avoid the mutagenesis issue of these core structures, we examined various functional groups at the C9 or N9 position of 2,7-diaminofluorene or 2,7-diaminocarbazole, respectively, through the Ames test in TA98 and TA100 mutants of Salmonella typhimurium LT-2. We discovered that, through proper alkyl substitution at the C9 or N9 position, 2,7-diaminofluorene and 2,7-diaminocarbazole moieties can be successfully employed in drug discovery without necessarily causing mutagenicity problems.

CARBAZOLE COMPOUND HAVING ANTI-VIRUS ACTIVITY

The present invention relates to a carbazole compound having anti-virus activity, and more particularly, to a novel compound selected from the group of consisting of a carbazole compound which shows excellent anti-proliferative efficacy against hepatitis C virus (HCV), a pharmaceutically acceptable salt thereof, a hydrate thereof, and an isomer thereof; an anti-virus pharmaceutical composition including the novel compound as an active ingredient; a pharmaceutical composition for preventing or treating liver diseases caused by hepatitis C virus; and a method of preparing the novel compound.

Effect of central linkages on mesophase behavior of imidazolium-based rod-like ionic liquid crystals

Two series of phenylbenzylether and benzanilide based rod-like imidazolium bromides and their nonionic precursors, the 1-phenyl-1H-imidazoles have been synthesized and the influence of the number and length of the alkyl chain(s) and the structure of the linking group in the aromatic core (-CH2O-, -COO-, -CONH-) on their mesophase self-assembly in ionic liquid crystalline phases were studied by POM, DSC and XRD. Upon decreasing the length of the N-terminal chain or by enlarging the number and length of the C-terminal chains, the sequence smectic (SmA)-hexagonal columnar (Colhex)-micellar cubic (CubI/Pm3n) was found for the ether based imidazolium salts; while only SmA and Colhex phases were observed for the related amides. The influence of the polarity of the central linkages, namely -CH 2O- and -CONH-, on the mesophase structure and stability is discussed and compared with related -COO- connected ILC.

Amphiphilic dendritic dipeptides and their self-assembly into helical pores

An amphiphilic dendritic dipeptide, comprises a dipeptide(s) comprising one or more of a naturally occurring or synthetic amino acids and a dendron. These are suitable for use in various formulations, films, coatings, membranes and sensors, among other ap

Molecular Recognition Directed Self-Assembly of Tubular Liquid Crystalline and Crystalline Supramolecular Architectures from Taper Shaped (15-Crown-5)methyl 3,4,5-Tris(p-alkyloxybenzyloxy)benzoates and (15-Crown-5-)methyl 3,4,5-Tris(p-dodecyloxy)benzoate

The syntheses and characterization of a series of (15-crown-5-)methyl 3,4,5-tris(p-alkyloxybenzyloxy)benzoates with alkyl tails of four 25, six 26, and twelve 27 carbon atoms and of (15-crown-5-)methyl 3,4,5-tris(p-dodecyloxybenzoate) 28 are described.Complexation of the crown ether endo-receptor with NaCF3SO3 destabilizes the crystalline phase of 25, 26, 27 and 28 and induces for the case of 27 and 28 the self-assembly of a supramolecular cylindral channel-like architecture which displays a thermotropic hexagonal columnar (Φh) mesophase.Most remarkably, in the crystalline phase of the complexes of 27 with NaCF3SO3 the cylindrical structure of the Φh mesophase is maintained.Characterization of these supramolecular architectures was performed by a combination of differential scanning calorimetry (DSC), thermal optical polarized microscopy, X-ray scattering and molecular modelling.A model is proposed in which a stratum of the column is formed by six molecules of 27 and 28 with the crown ether receptors residing in the column centre and the alkyl tails radiating toward the column periphery. endo-Recognition generated via the (15-crown-5)methyl receptor upon complexation, and exo-recognition provided by the tapered 3,4,5-tris(p-dodecyloxybenzyloxy)benzoate and 3,4,5-tris(p-dodecyloxy)benzoate fragments of 27 and 28 provide the driving force for the self-assembly of this cylindrical supramolecule.

Synthesis of New Liquid Crystalline Compounds based on 1,4-Diarylbuta-1,3-dienes

A group of (E,E)-1,4-diarylbuta-1,3-dienes, substituted in the para-position of one aryl ring by an alkoxy-group and in the para-position of the other aryl group by a cyano- or halogeno-group have been synthesised.The compounds are mesogenic and their phy

New Liquid Crystalline Compounds Based on 1,4-Diarylbuta-1,3-dienes

The first group of fully characterised mesogenic (E,E)-1,4-diarylbuta-1,3-dienes, substituted in the para-position of one aryl ring by an alkoxy-group and in the para-position of the other aryl group by a cyano- or halogeno-group has been prepared by a Wadsworth-Emmons procedure; their physical properties of high birefringence and low viscosity in combination make them particularly suitable for use in liquid crystal display devices when mixed with known liquid crystalline materials.