56926-26-2

Upstream product

• 56926-26-2 7-ethyl-octahydro-6H-pyrazino <1,2-c> pyrimidin-6-one 
• 4177-16-6 2-vinylpyrazine 
• 70264-01-6 2-(2-(N-carboethoxyethyl) aminoethyl) piperazine 
• 55496-64-5 2-(2-(N-ethyl)amino)pyrazine 
• 70263-79-5 2-(2-(N-carboethoxyethyl)amino ethyl)pyrazine 

Downstream Products

• 56926-26-2 (+)-3-ethyl-1,3,8-triazabicyclo<4.4.0>decan-2-one 
• 56926-26-2 (-)-3-ethyl-1,3,8-triazabicyclo<4.4.0>decan-2-one 
• 25143-13-9 (-)-3-ethyl-8-methyl-1,3,8-triazabicyclo<4.4.0>decan-2-one 
• 25143-13-9 (+)-3-ethyl-8-methyl-1,3,8-triazabicyclo<4.4.0>decan-2-one 
• 70263-81-9 7-Ethyloctahydro-2-[4,4-(di-p-fluorophenyl)butyl]-6H-pyrazino[1,2-c]pyrimidin-6-one hydrochloride 
• 25143-13-9 Centperazine 

Relevant academic research and scientific papers

A practical synthesis of 7-ethyl-octahydro-2-methyl-6H-pyrazino-[1,2-c]pyrimidin-6-one (Centperazine), an anti-filarial drug

7-Ethyl-octahydro-2-methyl-6H-pyrazino[1,2-c]pyrimidin-6-one (Centperazine) 1, an anti-filarial drug, currently undergoing phase 111 clinical trials has been synthesized by a short, practical and economical route suitable for large scale production. Thus 2-(2-ethylaminoethyl)pyrazine obtained from 2-vinylpyrazine and ethyl amine, on ethoxycarbonylation, catalytic hydrogenation, cyclo carbamation and N-methylation yields Centperazine 1 in 23.1% overall yield.

Studies in Potential Filaricides: Part 21--Resolution and Antifilarial Activity of Optical Antipodes of 3-Ethyl-8-methyl-1,3,8-triazabicyclodecan-2-one

The resolution of (+/-)-3-ethyl-8-methyl-1,3,8-triazabicyclodecan-2-one (3) using di-p-toluoyl-d-tartaric acid is described.Both the (+)- and (-)-enantiomers have been tested for their antifilarial activity against Litomosoides carinii infection in cotton rats.Though the laevo and dextro isomers of 3 have almost similar activity, the laevo isomer suppresses the microfilariaemia for a longer duration.

Diarylbutyl octahydropyrazinopyrimidinones and methods of medical treatment using them

2,3,4,7,8,9-Substituted octahydropyrazinopyrimidinones and acid addition salts thereof. A process for the preparation of said compounds. A pharmaceutical composition comprising such a compound and a conventional carrier. A process for the preparation of said composition. Method of medical treatment of human beings and animals using such compounds.