569336-75-0

Upstream product

• 64-10-8 phenyl carbamate 
• 83-13-6 diethyl 2-phenylmalonate 
• 19011-66-6 1,5-diphenyl-pyrimidine-2,4,6-trione 

Downstream Products

• 15900-37-5 1,5-diphenylhydantoin 
• 15900-36-4 2-anilino-5-phenyl-oxazol-4-one 
• 221679-71-6 5-amino-1,5-diphenyl-pyrimidine-2,4,6-trione 
• 221679-73-8 5-Azido-1,5-diphenylbarbituric acid 
• 569337-10-6 1-benzyl-5-phenyl-5-phenylcarbamoylhydantoin 
• 569337-08-2 5-phenyl-5-phenylcarbamoyl-1-propylhydantoin 
• 569336-93-2 5-benzylamino-1,5-diphenylbarbituric acid 
• 569336-92-1 1,5-diphenyl-5-isopropylaminobarbituric acid 
• 569336-91-0 1,5-diphenyl-5-propylaminobarbituric acid 

Relevant academic research and scientific papers

The aminobarbituric acid-hydantoin rearrangement

A general synthesis protocol for the generation of tri- and tetrasubstituted 5-carbamoylhydantoins is described. Starting from barbituric acids and following bromination and reaction with primary amines, 5-aminobarbituric acids 3a-s and 8 were prepared. C

A new one-pot synthesis of 5,5-disubstituted hydantoins from diethyl acetamidomalonates and ureas

A new one-pot synthesis of 5,5-disubstituted hydantoins 3 is reported. Diethyl 2-acetamido-2-alkylmalonates were found to react with substituted ureas in the presence of sodium ethoxide to produce the 5-alkyl-5- carbamoylhydantoins 3 a-e. The reaction involves a ring contraction of intermediate 5-aminobarbituric acids to the final hydantoin derivatives. The 5-aminobarbituric acids 2 d-f were prepared from azido derivatives 6 d-f. On treatment with sodium ethoxide, 2 d-f underwent the rearrangement to afford the hydantoins 3 d-f.