5694-22-4

Upstream product

• 62-53-3 aniline 
• 104-55-2 3-phenyl-propenal 
• 14181-75-0 N-(2-Phenylethenylidene)aniline 
• 536-74-3 phenylacetylene 
• 103-64-0 bromostyrene 

Downstream Products

• 46818-96-6 C₁₅H₁₇N₂⁽¹⁺⁾ 

Relevant academic research and scientific papers

Hydroamination of phenylacetylene in the presence of gold-containing catalytic systems supported on carriers modified by ionic liquids

Ternary systems based on gold nanoparticles stabilized in ionic liquids and loaded on the supports of various nature have been prepared for the first time. The gold-containing systems obtained demonstrate activity in Markovnikov regioselective hydroamination of phenylacetylene with aniline. Catalytic properties of the gold systems synthesized depend both on the carrier structure and on the nature of the ionic liquid applied (polarity, presence of functional groups).

Facile Synthesis and Isolation of Secondary Amines via a Sequential Titanium(IV)-Catalyzed Hydroamination and Palladium-Catalyzed Hydrogenation

An atom economical and catalytic route for the synthesis of aryl- and alkyl-substituted secondary amines has been developed. Using a bis(amidate)bis(amido)titanium(IV) precatalyst, the hydroamination of terminal alkynes with a range of amines results in the selective formation of the anti-Markovnikov product. The crude enamine/imine mixtures are effectively hydrogenated using palladium on carbon (Pd/C) and H2 to afford the corresponding secondary amine in excellent yields. Simple work-up procedures allow for the isolation of pure compounds while avoiding purification via column chromatography.

One-pot reductive amination of araldehydes by aniline using borohydride with CeCl3·7H2O as catalyst

A one-pot, two-step reductive amination of araldehydes or acetophenones with anilines using NaBH4as a cheap hydride source and catalysed by CeCl3·7H2O has been achieved in EtOH at room temperature in good yields.

Nickel catalyzed addition of -NH- containing compounds to vinyl and aryl halides

A process for producing unsaturated nitrogen containing compounds such as enamides, enamines and aryl amines/amides is disclosed. A vinyl halide or aryl halide is reacted with an -NH- containing compound in the presence of a catalytic amount of a catalyst precursor composition comprising zero-valent nickel and an organophosphine ligand. One step coupling of vinyl halides and aryl halides with -NH- containing compounds is made possible by practice of this invention.