56962-00-6

Basic information

• Product Name: 2-amino-3-chlorophenol
• Synonyms: 2-amino-3-chlorophenol;2-Hydroxy-6-chloroaniline;Phenol,2-aMino-3-chloro-
• CAS NO: 56962-00-6
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.57094
• Mol File: 56962-00-6.mol
• Article Data: 12

Chemical Properties

• Melting Point: 122 °C
• Boiling Point: 242.6 °C at 760 mmHg
• Flash Point: 100.5 °C
• Appearance: /
• Density: 1.406 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.79±0.10(Predicted)
• CAS DataBase Reference: 2-amino-3-chlorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-3-chlorophenol(56962-00-6)
• EPA Substance Registry System: 2-amino-3-chlorophenol(56962-00-6)

Safety Data

• Hazardous Substances Data: 56962-00-6(Hazardous Substances Data)

Usage

General Description

2-amino-3-chlorophenol is a chemical compound with the molecular formula C6H6ClNO. It is a substituted phenol with a chlorine atom and an amino group attached to the phenol ring. 2-amino-3-chlorophenol is often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also known for its use in the production of hair dyes and colorants. 2-amino-3-chlorophenol is considered to be toxic and hazardous to the environment, and proper precautions should be taken when handling and disposing of this chemical.

Upstream product

• 17802-02-7 2-nitro-3-chlorophenol 
• 3296-07-9 1-azido-2-chlorobenzene 
• 934537-35-6 N-(2-chloro-6-methoxyphenyl)-2,2-dimethylpropionamide 
• 33768-49-9 N-(2-methoxyphenyl)pivalamide 
• 90-04-0 2-methoxy-phenylamine 
• 64182-61-2 1-chloro-3-fluoro-2-nitrobenzene 
• 158966-62-2 6-chloro-o-anisidine 
• 74993-54-7 O-(m-chloro-phenyl)-hydroxylamine 

Downstream Products

• 1345459-58-6 2-bromo-2,2-difluoro-N-(2-hydroxy-6-chlorophenyl)acetamide 
• 1426320-93-5 2-amino-5-bromo-3-chlorophenol 
• 943443-12-7 4-chloro-benzoxazole 
• 1155264-46-2 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine 
• 1256250-76-6 C₂₉H₃₄N₂O₄ 
• 1256254-54-2 C₃₀H₃₆N₂O₄ 
• 1155288-89-3 C₃₁H₃₁ClN₂O₄ 
• 1154740-66-5 6-bromo-5-chloro-2H-1,4-benzoxazin-3(4H)-one 
• 1154740-67-6 C₈H₇BrClNO 
• 167388-17-2 4,6-dibromo-2,3-dichloro-phenol 
• 64037-10-1 4-Chlor-2-amino-benzoxazol 
• 858854-82-7 3-chloro-2-iodo-phenol 
• 576-24-9 2,3-dichlorophenol 
• 1446332-73-5 ethyl 2-(4-chlorobenzo[d]oxazol-2-yl)acetate 

Relevant articles and documents

ANTIBIOTIC COMPOUNDS

The present invention relates to antibiotic compounds of formula (I), to compositions containing these compounds and to methods of treating bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Gram-positive and/or Gram-negative bacteria, and in particular in the treatment of infection with, and diseases caused by, Neisseria gonorrhoeae.

CONDENSED HETEROCYCLIC COMPOUND

A compound represented by the general formula (I) [R1 represents a C1-6 alkyl group, a halogen atom, or the like; A represents a phenylene group, or the like; X represents —CH(R3)—, —O—, —NH—, or the like; Y represents —O—, —NH—, —N═, or —S—; . . . represents a single bond or double bond; n represents 1 to 3; R2 represents a C1-6 alkyl group, a C1-6 alkoxy group, or the like; and R3 represents hydrogen atom, a C1-6 alkyl group, or the like], or a salt thereof which has a blood LDL cholesterol-reducing action, and is useful as an active ingredient of medicaments.

Difluoromethylbenzoxazole pyrimidine thioether derivatives: A novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors

This paper reports the synthesis and antiviral properties of new difluoromethylbenzoxazole (DFMB) pyrimidine thioether derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors. By use of a combination of structural biology study and traditional medicinal chemistry, several members of this novel class were synthesized using a single electron transfer chain process (radical nucleophilic substitution, SRN1) and were found to be potent against wild-type HIV-1 reverse transcriptase, with low cytotoxicity but with moderate activity against drug-resistant strains. The most promising compound 24 showed a significant EC50 value close to 6.4 nM against HIV-1 IIIB, a moderate EC50 value close to 54 μM against an NNRTI resistant double mutant (K103N + Y181C), but an excellent selectivity index >15477 (CC50 > 100 μM).