569653-86-7

Upstream product

• 569652-89-7 tert-butyl 4-(4-benzylpiperazin-1-yl)-4-cyanopiperidine-1-carboxylate 
• 569653-06-1 4-(4-benzyl-piperazin-1-yl)-4-isobutyl-piperidine-1-carboxylic acid tert-butyl ester 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 569653-35-6 1-[4-(4-benzyl-piperazin-1-yl)-4-isobutyl-piperidin-1-yl]-ethanone 
• 569653-27-6 1-benzyl-4-(4-isobutyl-piperidin-4-yl)-piperazine 
• 569653-63-0 1-(4-isobutyl-4-piperazin-1-yl-piperidin-1-yl)-ethanone 
• 444583-56-6 1-{[1-carboxy-2-(4-chloro-phenyl)-ethylcarbamoyl]-methyl}-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Privileged structure based ligands for melanocortin receptors-4,4-Disubstituted piperidine derivatives

Homologation and cyclization back to the chiral methine of compound 3 yields achiral 4,4-disubstituted piperidine privileged structures (e.g., 8a) useful in the construction of melanocortin 4 receptor (MC4R) ligands. The piperidine nitrogen was replaced w