569652-89-7

Upstream product

• 2759-28-6 1-phenylmethylpiperazine 
• 7677-24-9 trimethylsilyl cyanide 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Downstream Products

• 569653-27-6 1-benzyl-4-(4-isobutyl-piperidin-4-yl)-piperazine 
• 569653-31-2 1-benzyl-4-(1-ethyl-4-isobutyl-piperidin-4-yl)-piperazine 
• 569653-35-6 1-[4-(4-benzyl-piperazin-1-yl)-4-isobutyl-piperidin-1-yl]-ethanone 
• 569653-29-8 1-benzyl-4-(4-isobutyl-1-methanesulfonyl-piperidin-4-yl)-piperazine 
• 569653-33-4 1-[4-(4-benzyl-piperazin-1-yl)-4-isobutyl-piperidin-1-yl]-2-methyl-propan-1-one 
• 569653-84-5 1-({1-(4-chloro-benzyl)-2-[4-(1-ethyl-4-isobutyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-methyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 569653-76-5 1-({1-(4-chloro-benzyl)-2-[4-(4-isobutyl-1-isopropyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-methyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 569653-86-7 1-{[2-[4-(1-acetyl-4-isobutyl-piperidin-4-yl)-piperazin-1-yl]-1-(4-chloro-benzyl)-2-oxo-ethylcarbamoyl]-methyl}-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 569653-83-4 1-({1-(4-chloro-benzyl)-2-[4-(4-isobutyl-1-methanesulfonyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-methyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 569653-85-6 1-({1-(4-chloro-benzyl)-2-[4-(4-isobutyl-1-isobutyryl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-methyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 569653-06-1 4-(4-benzyl-piperazin-1-yl)-4-isobutyl-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

SUBSTITUTED AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN

The present invention relates to substituted amide derivatives of formula (I) having dual pharmacological activity towards both the sigma (σ) receptor, and the p-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

Privileged structure based ligands for melanocortin receptors-4,4-Disubstituted piperidine derivatives

Homologation and cyclization back to the chiral methine of compound 3 yields achiral 4,4-disubstituted piperidine privileged structures (e.g., 8a) useful in the construction of melanocortin 4 receptor (MC4R) ligands. The piperidine nitrogen was replaced w