569657-87-0Relevant academic research and scientific papers
Synthesis and activity of a C-8 keto pleuromutilin derivative
Springer, Dane M.,Sorenson, Margaret E.,Huang, Stella,Connolly, Timothy P.,Bronson, Joanne J.,Matson, James A.,Hanson, Ronald L.,Brzozowski, David B.,LaPorte, Thomas L.,Patel, Ramesh N.
, p. 1751 - 1753 (2003)
A C-8 keto pleuromutilin derivative has been synthesized from the biotransformation product 8-hydroxy mutilin. A key step in the process was the selective oxidation at C-8 of 8-hydroxy mutilin using tetrapropylammonium perruthenate. The presence of the C-8 keto group precipitated interesting intramolecular chemistry to afford a compound (10) with a novel pleuromutilin-derived ring system.
