Bioorganic and Medicinal Chemistry Letters p. 1751 - 1753 (2003)
Update date:2022-09-26
Topics:
Springer, Dane M.
Sorenson, Margaret E.
Huang, Stella
Connolly, Timothy P.
Bronson, Joanne J.
Matson, James A.
Hanson, Ronald L.
Brzozowski, David B.
LaPorte, Thomas L.
Patel, Ramesh N.
A C-8 keto pleuromutilin derivative has been synthesized from the biotransformation product 8-hydroxy mutilin. A key step in the process was the selective oxidation at C-8 of 8-hydroxy mutilin using tetrapropylammonium perruthenate. The presence of the C-8 keto group precipitated interesting intramolecular chemistry to afford a compound (10) with a novel pleuromutilin-derived ring system.
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