56966-62-2

Basic information

• Product Name: 1-(4-BROMOPHENOXY)-2-NITROBENZENE
• Synonyms: 1-(4-BROMOPHENOXY)-2-NITROBENZENE;Nsc78380
• CAS NO: 56966-62-2
• Molecular Formula: C₁₂H₈BrNO₃
• Molecular Weight: 294.1
• Mol File: 56966-62-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 360.1 °C at 760 mmHg
• Flash Point: 171.6 °C
• Appearance: /
• Density: 1.563 g/cm³
• Vapor Pressure: 4.72E-05mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: 1-(4-BROMOPHENOXY)-2-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMOPHENOXY)-2-NITROBENZENE(56966-62-2)
• EPA Substance Registry System: 1-(4-BROMOPHENOXY)-2-NITROBENZENE(56966-62-2)

Safety Data

• Hazardous Substances Data: 56966-62-2(Hazardous Substances Data)

Usage

General Description

1-(4-Bromophenoxy)-2-nitrobenzene is a chemical compound with the molecular formula C12H8BrNO3. It is a nitrophenol derivative that contains a phenyl ring substituted with a bromine atom and a nitro group, as well as an ether linkage. 1-(4-Bromophenoxy)-2-nitrobenzene is commonly used in organic synthesis and chemical research, and it may have potential applications in pharmaceuticals, agrochemicals, and materials science. Its properties and reactivity make it a versatile building block for the synthesis of various organic compounds. Additionally, it is important to handle this compound with caution, as it may pose hazards to health and the environment.

InChI:InChI=1/C12H8BrNO3/c13-9-5-7-10(8-6-9)17-12-4-2-1-3-11(12)14(15)16/h1-8H

Upstream product

• 106-41-2 4-bromo-phenol 
• 23530-43-0 2-(N,N-dimethylaminosulfonyl)nitrobenzene 
• 88-73-3 2-Chloronitrobenzene 
• 2216-12-8 1-nitro-2-phenoxy-benzene 
• 68574-35-6 4-bromophenyl methanesulfonate 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 204847-20-1 benzoic acid-[2-(4-bromo-phenoxy)-anilide] 
• 858427-74-4 11-(4-cyano-phenyl)-dibenz[b,f][1,4]oxazepine-2-carbonitrile 
• 857542-38-2 4-(2-bromo-dibenz[b,f][1,4]oxazepin-11-yl)-benzonitrile 
• 873977-98-1 acetic acid-[5-bromo-2-(2,4-dibromo-phenoxy)-anilide] 
• 873977-31-2 N-(2-(2-bromophenoxy)-4-bromophenyl)acetamide 
• 860577-49-7 acetic acid-[2-(2,4-dibromo-phenoxy)-anilide] 
• 873386-17-5 acetic acid-[4-bromo-2-(4-bromo-phenoxy)-anilide] 
• 204847-21-2 N-(2-(2-bromophenoxy)phenyl)acetamide 
• 204847-19-8 acetic acid-[2-(4-bromo-phenoxy)-anilide] 
• 187845-86-9 2-(2,4-dibromo-phenoxy)-aniline 
• 873980-35-9 4-bromo-2-(4-bromo-phenoxy)-aniline 
• 72405-09-5 5-bromo-2-(2,4-dibromo-phenoxy)-aniline 
• 187845-85-8 (2,4-dibromo-phenyl)-(2-nitro-phenyl)-ether 
• 72405-05-1 (4-bromo-2-nitro-phenyl)-(2,4-dibromo-phenyl)-ether 

Relevant articles and documents

Ligand-free copper-catalyzed O-arylation of arenesulfonamides with phenols: An unusual approach to biaryl ether synthesis

An unprecedented ligand-free copper-catalyzed O-arylation of arenesulfonamides with phenols has been developed. Thus, a range of unsysmmetric biaryl ethers were synthesized in excellent yields. The reaction occurs efficiently with excellent regioselectivity through the cleavage of Cary–S bond and with a good tolerance of functional groups on the phenyl ring of phenols. The reaction is appreciated for its readily accessible substrates, mild conditions, and simple operation under air.

Arylmethanesulfonates are convenient latent phenols in the nucleophilic aromatic substitution reaction

The methanesulfonyl protecting group for a phenol is conveniently unmasked under the conditions of the S(N)Ar reaction with an activated aryl halide, producing diarylether products directly. The method is advantageous when the preparation of a phenol substrate requires O-protection, since the selection of the robust methanesulfonate as a latent phenol obviates a deprotection step prior to the S(N)Ar reaction.