569669-47-2

Upstream product

• 2228-12-8 4-methyl-6-mercapto-2-phenylpyrimidine-5-carbonitrile 
• 128529-81-7 3-Amino-4-methyl-6-phenyl-thieno<2,3-d>pyrimidin-2-carbonsaeureethylester 
• 128503-05-9 4-(5-Cyano-6-methyl-2-phenyl)pyrimidinyl (ethoxycarbonyl)methyl sulfide 
• 104-88-1 4-chlorobenzaldehyde 
• 569669-28-9 5-amino-4-methyl-2-phenylthieno[2,3-d]pyrimidine-6-carbohydrazid 

Relevant academic research and scientific papers

Synthesis and reactions of some new thienopyrimidines

4-Methyl-6-mercapto-2-phenylpyrimidine-5-carbonitrile (1) was reacted with different halo compounds, namely ethylchloroacetate, chloroacetone, bromoacetanilide, p-chlorobromoacetanilide, and p-methoxy chloroacetanilide in ethanol in the presence of sodium acetate yielded the corresponding S-alkylated derivatives (2a-e). The latter compounds underwent cyclization into thienopyrimidines (4a-e) upon treatment with sodium ethoxide in ethanol. The reaction of (4a) with hydrazine hydrate led to the formation of 5-amino-4-methyl-2-phenylthieno[2,3-d]pyrimidine-2-carbohydrazide (5). Compound (5) was reacted with a variety of reagents to produce other new thienopyrimidines as well as oxadiazolylthienopyrimidines (6, 11).