128503-05-9

Upstream product

• 105-36-2 ethyl bromoacetate 
• 2228-12-8 4-methyl-6-mercapto-2-phenylpyrimidine-5-carbonitrile 
• 2228-12-8 6-methyl-4-phenyl-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile 
• 105-39-5 chloroacetic acid ethyl ester 
• 532-55-8 Benzoyl isothiocyanate 

Downstream Products

• 128529-81-7 3-Amino-4-methyl-6-phenyl-thieno<2,3-d>pyrimidin-2-carbonsaeureethylester 
• 569669-47-2 5-Amino-4-methyl-2-phenyl-thieno[2,3-d]pyrimidine-6-carboxylic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 569669-46-1 5-Amino-4-methyl-2-phenyl-thieno[2,3-d]pyrimidine-6-carboxylic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 569669-45-0 5-Amino-4-methyl-2-phenyl-thieno[2,3-d]pyrimidine-6-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide 
• 569669-29-0 5-amino-6-[4,5-dihydro-5-thioxo-1,3,4-oxadiazol-3-yl]-4-methyl-2-phenylthieno[2,3-d]pyrimidine 
• 569669-28-9 5-amino-4-methyl-2-phenylthieno[2,3-d]pyrimidine-6-carbohydrazid 
• 569669-30-3 5-amino-4-methyl-2-phenylthieno[2,3-d]pyrimidine-6-carbazide 
• 487005-31-2 6-[4,5-dihydro-5-thioxo-1,3,4-oxadiazol-3-yl]-4-methyl-2-phenyl-5-[1-pyrrolyl]-thieno[2,3-d]pyrimidine 
• 153776-14-8 9-Methyl-7-phenyl-thieno<2,3-d:4,5-d'>dipyrimidin-4(3H)-on 

Relevant academic research and scientific papers

Synthesis and reactions of some new thienopyrimidines

4-Methyl-6-mercapto-2-phenylpyrimidine-5-carbonitrile (1) was reacted with different halo compounds, namely ethylchloroacetate, chloroacetone, bromoacetanilide, p-chlorobromoacetanilide, and p-methoxy chloroacetanilide in ethanol in the presence of sodium acetate yielded the corresponding S-alkylated derivatives (2a-e). The latter compounds underwent cyclization into thienopyrimidines (4a-e) upon treatment with sodium ethoxide in ethanol. The reaction of (4a) with hydrazine hydrate led to the formation of 5-amino-4-methyl-2-phenylthieno[2,3-d]pyrimidine-2-carbohydrazide (5). Compound (5) was reacted with a variety of reagents to produce other new thienopyrimidines as well as oxadiazolylthienopyrimidines (6, 11).

Electrolytic Partial Fluorination of Organic Compounds. 19. A Novel Synthesis of Fluorothienopyridines Using Anodic Fluorination of Heterocyclic Sulfides as a Key Step

Highly regioselective anodic monofluorination of 2-pyridyl and 4-pyrimidinyl sulfides bearing various electron-withdrawing groups were successfully carried out.The fluorinated sulfides were easily converted into 2-fluorothienopyridines in good yields.