56970-24-2

Basic information

• Product Name: 2-METHOXY-[1,1'-BIPHENYL]-4-AMINE
• Synonyms: 3-Methoxy-4-aminodiphenyl;3-methoxy-4-biphenylamin;3-Methoxybiphenylamine;2-methoxy-4-phenyl-aniline;3-Methoxy-4-phenylaniline;2-methoxybiphenyl-4-amine;2-METHOXY-[1,1'-BIPHENYL]-4-AMINE
• CAS NO: 56970-24-2
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 199.25
• EINECS: 1312995-182-4
• Mol File: 56970-24-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 336.78°C (rough estimate)
• Flash Point: 146.9 °C
• Appearance: /
• Density: 1.0671 (rough estimate)
• Vapor Pressure: 0.000411mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-METHOXY-[1,1'-BIPHENYL]-4-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-[1,1'-BIPHENYL]-4-AMINE(56970-24-2)
• EPA Substance Registry System: 2-METHOXY-[1,1'-BIPHENYL]-4-AMINE(56970-24-2)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 56970-24-2(Hazardous Substances Data)

Usage

General Description

2-Methoxy-[1,1'-biphenyl]-4-amine is a chemical compound that belongs to the class of organic compounds known as diphenylmethanes. 2-METHOXY-[1,1'-BIPHENYL]-4-AMINE is characterized by two phenyl rings, a methoxy group, and an amino group. The presence of these functional groups typically influences its behavior and reactivity. The biphenyl part of the compound adds to its structural complexity, often leading to unique chemical properties. Notably, the amine group usually makes the compound basic, while the methoxy group can influence its polarity and solubility. Information on its specific uses or functions might vary, but such chemicals are often found in industrial manufacture or as intermediates in creating pharmaceutical substances. It's important to handle such chemicals with care due to potential health and environmental hazards.

InChI:InChI=1/C13H13NO/c1-15-13-9-11(14)7-8-12(13)10-5-3-2-4-6-10/h2-9H,14H2,1H3

Upstream product

• 19056-40-7 4-bromo-3-methoxyaniline 
• 98-80-6 phenylboronic acid 
• 15862-01-8 2-methoxy-4-nitrobiphenyl 

Relevant articles and documents

Bifunctional Naphtho[2,3- d][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects in Vitro and in Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production

Human dihydroorotate dehydrogenase (hDHODH) is an attractive target for cancer therapy. Based on its crystal structure, we designed and synthesized a focused compound library containing the structural moiety of 1,4-benzoquinone, which possesses reactive oxygen species (ROS) induction capacity. Compound 3s with a naphtho[2,3-d][1,2,3]triazole-4,9-dione scaffold exhibited inhibitory activity against hDHODH. Further optimization led to compounds 11k and 11l, which inhibited hDHODH activity with IC50 values of 9 and 4.5 nM, respectively. Protein-ligand cocrystal structures clearly depicted hydrogen bond and hydrophobic interactions of 11k and 11l with hDHODH. Compounds 11k and 11l significantly inhibited leukemia cell and solid tumor cell proliferation and induced ROS production, mitochondrial dysfunction, apoptosis, and cell cycle arrest. Nanocrystallization of compound 11l displayed significant in vivo antitumor effects in the Raji xenograft model. Overall, this study provides a novel bifunctional compound 11l with hDHODH inhibition and ROS induction efficacy, which represents a promising anticancer lead worthy of further exploration.

DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS

The present invention provides novel 6-substituted [1,2,4]triazolo[4,3-b]pyridazines that are agonists of Rev-Erb. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the activation of Rev-Erb has therapeutic effects, for instance in inflammatory and circadian rhythm-related disorders or cardiometabolic diseases.

β-methoxy acrylic acid derivatives, method for preparing same, and use of said derivatives as pesticides

A subject of the invention is the products of formula (I): STR1 in which: R1, R2 and R3, identical or different, represent a linear, branched or cyclic alkyl radical, an alkenyl or alkynyl radical, containing up to 8 carbon atoms, optionally substituted by one or more halogen atoms, an aryl radical optionally substituted by one or more halogen atoms, one or more hydroxyl radicals, one or more linear or branched alkyl radicals, optionally substituted by one or more halogen atoms, one or more O-alkyl or S-alkyl radicals optionally substituted by one or more halogen atoms, X represents a hydrogen atom, a halogen atom, an alkyl, alkenyl, alkynyl, O-alkyl, O-alkenyl, O-alkynyl, S-alkyl, S-alkenyl or S-alkynyl radical, optionally substituted by one or more halogen atoms and containing up to 11 carbon atoms, an aryl radical containing up to 14 carbon atoms, a C N, NO2, NH2, STR2 CO2 alk3 radical, alk1, alk2 and alk3, identical to or different from each other, representing an alkyl radical containing up to 8 carbon atoms, R4 represents one of the values indicated above for X with the exception of hydrogen.