56970-25-3

Basic information

• Product Name: 6-Chloro-biphenyl-3-ylamine
• Synonyms: 6-Chloro-biphenyl-3-ylamine;6-Chloro-[1,1'-biphenyl]-3-amine
• CAS NO: 56970-25-3
• Molecular Formula: C₁₂H₁₀ClN
• Molecular Weight: 203.6675
• Mol File: 56970-25-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 354.2±30.0 °C(Predicted)
• Appearance: /
• Density: 1.205±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.70±0.10(Predicted)
• CAS DataBase Reference: 6-Chloro-biphenyl-3-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-biphenyl-3-ylamine(56970-25-3)
• EPA Substance Registry System: 6-Chloro-biphenyl-3-ylamine(56970-25-3)

Safety Data

• Hazardous Substances Data: 56970-25-3(Hazardous Substances Data)

Usage

Composition

Biphenyl core with a chlorine atom attached to the third carbon and an amine group attached to the third carbon

Uses

Reagent in organic synthesis for preparation of pharmaceuticals and agrochemicals

Applications

Research and development in pharmaceutical and chemical industries

Hazards

Potential hazards and toxicity, requiring careful handling

Upstream product

• 2243-47-2 3-biphenyl amine 
• 100-00-5 4-chlorobenzonitrile 
• 74534-15-9 1-chloro-2-iodo-4-nitrobenzene 
• 573764-31-5 3-iodo-4-chloroaniline 
• 98-80-6 phenylboronic acid 
• 29608-76-2 2-chloro-5-nitro-1,1'-biphenyl 

Downstream Products

• 1369416-35-2 C₂₀H₁₄ClN₃O 
• 1166975-60-5 (3-biphenyl-4-ylmethyl-3H-imidazol-4-ylmethyl)-(6-chloro-biphenyl-3-yl)-amine 
• 1166977-21-4 (6-chloro-biphenyl-3-yl)-[3-(3-nitro-biphenyl-4-ylmethyl)-3H-imidazol-4-ylmethyl]-amine 

Relevant articles and documents

Catalyst-Controlled Regioselective Chlorination of Phenols and Anilines through a Lewis Basic Selenoether Catalyst

We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis basic selenoether catalyst. The selenoether catalyst resulted in comparable selectivities to our previously reported bis-thiourea ortho-selective catalyst, with a catalyst loading as low as 1%. The new catalytic system also allowed us to extend this chemistry to obtain excellent ortho-selectivities for unprotected anilines. The selectivities of this reaction are up to >20:1 ortho/para, while the innate selectivities for phenols and anilines are approximately 1:4 ortho/para. A series of preliminary studies revealed that the substrates require a hydrogen-bonding moiety for selectivity.

Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents

New dialkylimidazole based sterol 14α-demethylase inhibitors were prepared and tested as potential anti-Trypanosoma cruzi agents. Previous studies had identified compound 2 as the most potent and selective inhibitor against parasite cultures. In addition, animal studies had demonstrated that compound 2 is highly efficacious in the acute model of the disease. However, compound 2 has a high molecular weight and high hydrophobicity, issues addressed here. Systematic modifications were carried out at four positions on the scaffold and several inhibitors were identified which are highly potent (EC50 1 nM) against T. cruzi in culture. The halogenated derivatives 36j, 36k, and 36p, display excellent activity against T. cruzi amastigotes, with reduced molecular weight and lipophilicity, and exhibit suitable physicochemical properties for an oral drug candidate.