56979-64-7Relevant academic research and scientific papers
The Synthesis of Chiral α-Aryl α-Hydroxy Carboxylic Acids via RuPHOX-Ru Catalyzed Asymmetric Hydrogenation
Guo, Huan,Li, Jing,Liu, Delong,Zhang, Wanbin
, p. 3665 - 3673 (2017/09/11)
A ruthenocenyl phosphino-oxazoline-ruthenium complex (RuPHOX?Ru) catalyzed asymmetric hydrogenation of α-aryl keto acids has been successfully developed, affording the corresponding chiral α-aryl α-hydroxy carboxylic acids in high yields and with up to 97% ee. The reaction could be performed on a gram scale with a relatively low catalyst loading (up to 5000 S/C) and the resulting products can be transformed to several chiral building blocks, biologically active compounds and chiral drugs. (Figure presented.).
Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors
Mellon, Christophe,Aspiotis, Renee,Black, Cameron W.,Bayly, Christopher I.,Grimm, Erich L.,Giroux, Andre,Han, Yongxin,Isabel, Elise,McKay, Daniel J.,Nicholson, Donald W.,Rasper, Dita M.,Roy, Sophie,Tam, John,Thornberry, Nancy A.,Vaillancourt, John P.,Xanthoudakis, Steven,Zamboni, Robert
, p. 3886 - 3890 (2007/10/03)
Caspase 3 is a cysteinyl protease that mediates apoptotic cell death. Its inhibition may have an important impact in the treatment of several degenerative diseases. The P1 aspartic acid residue is a required element of recognition for this enzy
