5698-29-3Relevant articles and documents
Method for preparing lactone compound by cycloalkane compound through oxidation
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Paragraph 0064; 0065; 0116-0119, (2019/02/04)
The invention discloses a method for preparing a lactone compound by a cycloalkane compound through oxidation. The method comprises the following steps of using the cycloalkane compound as the raw material, and further oxidizing by a catalysis system under the oxygen-containing atmosphere, so as to obtain the lactone compound, wherein the catalysis system comprises a catalyst and an additive; thecatalyst is selected from a cyclic organic nitrogen and oxygen free radical precursor in formulas (I), (II), (III) and (IV); in the formula, R1, R2 and R3 are independently selected from hydrogen atom, alkyl, cycloalkyl, aryl, heterocycle, hydroxyl, nitryl, or halogen, or at least two of R1, R2 and R3 form loops; the additive is selected from an aldehyde compound. The preparation method has the advantages that the corresponding lactone is prepared by the cycloalkane compound through a one-step method; the conditions are mild, the safety is high, and the metal catalytic oxidization is avoided;the selectivity of the target product, namely the lactone compound, is high. The formulae are shown in the description.