56984-32-8

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE is used as a pharmaceutical intermediate for the synthesis of various drugs and medicinal compounds. Its unique structure allows for the development of new therapeutic agents with potential applications in treating a range of diseases and medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE serves as a key intermediate in the production of pesticides, herbicides, and other crop protection agents. Its chemical properties enable the creation of effective and targeted agrochemicals that can improve crop yields and protect against pests and diseases.
Used in Material Science:
ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE is utilized in material science for the development of novel materials with specific properties. Its incorporation into polymers, coatings, and other materials can enhance their performance, durability, and functionality, making them suitable for various applications in industries such as electronics, automotive, and aerospace.

InChI:InChI=1/C7H9ClN2O2/c1-3-12-7(11)5-4-9-10(2)6(5)8/h4H,3H2,1-2H3

Upstream product

• 31037-02-2 ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate 
• 88398-78-1 1-methyl-5-hydroxypyrazol-4-carboxylic acid ethyl ester 
• 37622-90-5 4-ethoxycarbonylpyrazole 
• 85290-80-8 ethyl 1-methylpyrazole-4-carboxylate 

Downstream Products

• 54367-66-7 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid 
• 937743-04-9 C₂₁H₂₅N₃OS 
• 937743-28-7 C₂₂H₂₆FN₃O₂ 
• 937743-27-6 C₂₄H₂₉N₃O₄ 
• 937743-23-2 C₂₃H₂₆F₃N₃O₂ 
• 937743-22-1 C₂₂H₂₅Cl₂N₃O₂ 
• 937743-24-3 C₂₃H₂₆F₃N₃O₃ 
• 937743-25-4 C₂₄H₃₁N₃O₄ 
• 937743-29-8 C₂₃H₂₆N₄O₂ 
• 1609938-67-1 1-methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid 

Relevant academic research and scientific papers

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

Amide compound and its preparation method, pharmaceutical composition and use thereof

The present invention relates to amide compounds as shown by structural formula (I). The compounds are low absorbable TGR5 agonists and can be used to treat type II diabetes, obesity, liver or intestine chronic inflammatory diseases.

Discovery and structure-activity relationship study of 4-phenoxythiazol-5-carboxamides as highly potent TGR5 agonists

A novel therapy that stimulates endogenous glucagon-like peptide-1 (GLP-1) secretion by Takeda G-protein-coupled receptor 5 (TGR5) agonists might be a superior alternative for the treatment of type 2 diabetes mellitus. A series of 4-phenoxythiazol-5-carboxamides were developed as highly potent TGR5 agonists using a bioisosteric replacement strategy based on the scaffold of 4-phenoxynicotinamides. The structure-activity relationship on the bottom phenyl ring and the thiazole ring was extensively studied, and the 2-methylthiazole derivatives 30c and e displayed the best in vitro potency toward human TGR5, with EC50 values of approximately 1 nM. While endowed with excellent in vitro potency, the 2-methyl-thiazoles were flawed with high microsomal clearance.

HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON 11- -HYDROXYSTEROID DEHYDROGENASE TYPE I

Disclosed is a compound useful as a type I 11βhydroxysteroid dehydrogenase inhibitor. A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R1 is optionally substituted alkyl or the like, one of R2 and R4 is a group of formula: -Y-R5, wherein Y is -O- or the like, R5 is substituted alkyl (the substituent is optionally substituted cycloalkyl or the like), optionally substituted branched alkyl or the like, the other of R2and R4 is hydrogen or optionally substituted alkyl, R3 is a group of formula: -C(=O)-Z-R6, wherein Z is -NR7- or -NR7-W-, R6 is optionally substituted cycloalkyl or the like, R7 is hydrogen or optionally substituted alkyl, W is optionally substituted alkylene, X is =N- or the like, with the proviso that compounds wherein R2 is 2-(morphorino)ethoxy, R3 is N-(1-adamantyl)carbamoyl and R1 is benzyl are excluded.

Adamantyl-pyrazole carboxamides as inhibitors of 11B-hydroxysteroid dehydrogenase

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.

Synthesis of 5-Chloropyrazoles by Chlorodiazoniation with Sulfur Dioxide

A facile synthesis of 5-chloropyrazoles 4a-e from 5-aminopyrazoles 2a-e via diazotization followed by chlorodediazoniation is described.A new application of sulfur dioxide as a catalyst was demonstrated to be the best for the chlorodediazoniation of diazonium chlorides 3a-e.

Herbicidal pyrazole sulfonyl Imino-2H-1,2,4-thiadiazolo[2,3-a9 pyrimidines

Novel compounds of the formula: STR1 wherein R1 is a pyrazolyl group which may be substituted; R2 and R3 respectively are a lower alkyl group or a lower alkoxy group; and Z is CH or N, which are useful as herbicides.

Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides

1,5-Disubstituted-1H-pyrazole-4-carboxamide derivatives, useful as herbicides and aquatic algicides.