56984-32-8

Basic information

• Product Name: ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE
• Synonyms: ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE;ETHYL-5-CHLORO-1-METHYLPYRAZOLE-4-CARBOXYLATE;Ethyl 5-chloropyrazole-4-carboxylate
• CAS NO: 56984-32-8
• Molecular Formula: C₇H₉ClN₂O₂
• Molecular Weight: 188.61
• Mol File: 56984-32-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 327.3°Cat760mmHg
• Flash Point: 151.8°C
• Appearance: /
• Density: 1.371g/cm³
• Vapor Pressure: 0.00772mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.13±0.10(Predicted)
• CAS DataBase Reference: ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE(56984-32-8)
• EPA Substance Registry System: ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE(56984-32-8)

Safety Data

• Hazardous Substances Data: 56984-32-8(Hazardous Substances Data)

Usage

General Description

ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE is a chemical compound with the molecular formula C8H9ClN2O2. It is a pyrazole derivative with a chloromethyl group and an ethyl ester group. ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE has potential applications in the pharmaceutical, agrochemical, and material science industries. Its precise properties and uses are subject to further research and development.

InChI:InChI=1/C7H9ClN2O2/c1-3-12-7(11)5-4-9-10(2)6(5)8/h4H,3H2,1-2H3

Upstream product

• 85290-80-8 ethyl 1-methylpyrazole-4-carboxylate 
• 37622-90-5 4-ethoxycarbonylpyrazole 
• 88398-78-1 1-methyl-5-hydroxypyrazol-4-carboxylic acid ethyl ester 
• 31037-02-2 ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate 

Downstream Products

• 54367-66-7 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid 
• 937743-04-9 C₂₁H₂₅N₃OS 
• 937743-28-7 C₂₂H₂₆FN₃O₂ 
• 937743-27-6 C₂₄H₂₉N₃O₄ 
• 937743-23-2 C₂₃H₂₆F₃N₃O₂ 
• 937743-22-1 C₂₂H₂₅Cl₂N₃O₂ 
• 937743-24-3 C₂₃H₂₆F₃N₃O₃ 
• 937743-25-4 C₂₄H₃₁N₃O₄ 
• 937743-29-8 C₂₃H₂₆N₄O₂ 
• 1609938-67-1 1-methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid 

Relevant articles and documents

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

Discovery and structure-activity relationship study of 4-phenoxythiazol-5-carboxamides as highly potent TGR5 agonists

A novel therapy that stimulates endogenous glucagon-like peptide-1 (GLP-1) secretion by Takeda G-protein-coupled receptor 5 (TGR5) agonists might be a superior alternative for the treatment of type 2 diabetes mellitus. A series of 4-phenoxythiazol-5-carboxamides were developed as highly potent TGR5 agonists using a bioisosteric replacement strategy based on the scaffold of 4-phenoxynicotinamides. The structure-activity relationship on the bottom phenyl ring and the thiazole ring was extensively studied, and the 2-methylthiazole derivatives 30c and e displayed the best in vitro potency toward human TGR5, with EC50 values of approximately 1 nM. While endowed with excellent in vitro potency, the 2-methyl-thiazoles were flawed with high microsomal clearance.

Adamantyl-pyrazole carboxamides as inhibitors of 11B-hydroxysteroid dehydrogenase

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.