57000-48-3

Basic information

• Product Name: (5-METHOXY-1H-INDOL-3-YL)-ACETIC ACID HYDRAZIDE
• Synonyms: (5-METHOXY-1H-INDOL-3-YL)-ACETIC ACID HYDRAZIDE;5-METHOXYINDOLE-3-ACETIC ACID HYDRAZIDE
• CAS NO: 57000-48-3
• Molecular Formula: C11H13N3O2
• Molecular Weight: 219.24
• Product Categories: pharmacetical
• Mol File: 57000-48-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 540.6°Cat760mmHg
• Flash Point: 280.8°C
• Appearance: /
• Density: 1.302g/cm³
• Vapor Pressure: 9.37E-12mmHg at 25°C
• Refractive Index: 1.657
• CAS DataBase Reference: (5-METHOXY-1H-INDOL-3-YL)-ACETIC ACID HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (5-METHOXY-1H-INDOL-3-YL)-ACETIC ACID HYDRAZIDE(57000-48-3)
• EPA Substance Registry System: (5-METHOXY-1H-INDOL-3-YL)-ACETIC ACID HYDRAZIDE(57000-48-3)

Safety Data

• Hazardous Substances Data: 57000-48-3(Hazardous Substances Data)

Usage

General Description

(5-Methoxy-1H-indol-3-yl)-acetic acid hydrazide is a synthetic chemical compound that exhibits potential pharmaceutical properties. It is a derivative of indole, a heterocyclic organic compound that occurs naturally in plants and some animals. The compound has been studied for its potential applications in pharmaceutical research, particularly as a precursor in the synthesis of new medications with potential therapeutic benefits. Additionally, it may also have potential applications in the field of neuropharmacology and in the development of novel drugs to treat neurological disorders. Overall, the compound shows promise in the field of medicinal chemistry and drug development.

InChI:InChI=1/C11H13N3O2/c1-16-8-2-3-10-9(5-8)7(6-13-10)4-11(15)14-12/h2-3,5-6,13H,4,12H2,1H3,(H,14,15)

Upstream product

• 3471-31-6 5-methoxy-1H-indole-3-acetic acid 
• 57000-49-4 (5-methoxy-1H-indol-3-yl)acetic acid ethyl ester 

Relevant articles and documents

Novel N -Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential

Herein we present a new family of melatonin-based compounds, in which the acetamido group of melatonin has been bioisosterically replaced by a series of reversed amides and azoles, such as oxazole, 1,2,4-oxadiazole, and 1,3,4-oxadiazole, as well as other related five-membered heterocycles, namely, 1,3,4-oxadiazol(thio)ones, 1,3,4-triazol(thio)ones, and an 1,3,4-thiadiazole. New compounds were fully characterized at melatonin receptors (MT1R and MT2R), and results were rationalized by superimposition studies of their structures to the bioactive conformation of melatonin. We also found that several of these melatonin-based compounds promoted differentiation of rat neural stem cells to a neuronal phenotype in vitro, in some cases to a higher extent than melatonin. This unique profile constitutes the starting point for further pharmacological studies to assess the mechanistic pathways and the relevance of neurogenesis induced by melatonin-related structures.