57009-21-9

Basic information

• Product Name: 4H-1-Benzopyran-6-carboxylic acid, 4-oxo-2-phenyl-
• CAS NO: 57009-21-9
• Molecular Formula: C16H10O4
• Molecular Weight: 266.253
• Mol File: 57009-21-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-6-carboxylic acid, 4-oxo-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-6-carboxylic acid, 4-oxo-2-phenyl-(57009-21-9)
• EPA Substance Registry System: 4H-1-Benzopyran-6-carboxylic acid, 4-oxo-2-phenyl-(57009-21-9)

Safety Data

• Hazardous Substances Data: 57009-21-9(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 16357-40-7 3-acetyl-4-hydroxybenzoic acid 
• 145602-97-7 3-trans-cinnamoyl-4-hydroxy-benzoic acid 
• 7446-08-4 selenium(IV) oxide 
• 71-41-0 pentan-1-ol 

Relevant articles and documents

COMPOUNDS FOR IMMUNOPOTENTIATION

Methods of stimulating an immune response and treating patients responsive thereto with 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-diones, staurosporine analogs, derivatized pyridazines, chromen-4-ones, indolinones, quinazolines, nucleoside analogs, and other small molecules are disclosed.

Synthesis of carboxylated flavonoids as new leads for LTD4 antagonists

A series of 3'- and 5'-carboxylated chalcones, 6- or 8-carboxylated flavones and 6-carboxylated flavanones, -flavanols and -flavans were prepared. The compounds were tested for their inhibitory activities against leukotriene D4 (LTD4) induced contraction of guinea-pig ileum. A new and convenient synthetic route to 3-acetyl-2-hydroxybenzoic acid (Id), a key intermediate for the synthesis of 3'-carboxy-2'-hydroxychalcones and 8-carboxylated flavones, was developed. The activities of the tested compounds ranged from 0 to 63% inhibition at 10-5 M drug concentration against a single challenge of 10-8 M LTD4. Several compounds were tested in a radioligand binding assay against [3H]LTD4 on guinea-pig lung membrane. The quinoline-containing chalcone 12 and flavone 17 were found to exhibit significant but weak affinities for LTD4 receptors with pK(D)-values of 4.95 and 4.83, respectively and are interesting lead structures for the development of rigid LTD4 antagonists. In contrast, the rest of the compounds tested in the binding assay did not show significant displacement of the radioligand, implying that for these compounds the functional activity is probably not caused by competitive antagonism at the LTD4 receptor. The exact mechanism of the relaxant activity remains unclear.

5:6-Benzo δ-pyrone derivatives and process for their preparation

Substituted 6-carboxy flavones are disclosed, such as, for instance, 6-carboxy-2'-isopropoxy-flavone. Such flavone derivatives possess anti-allergic activity, decrease airway resistance and increase pulmonary compliance. In addition, the compounds possess