57009-75-3

Basic information

• Product Name: 2-(4-fluorophenyl)-1,3-dithiane
• Synonyms: 2-(4-fluorophenyl)-1,3-dithiane
• CAS NO: 57009-75-3
• Molecular Formula: C₁₀H₁₁FS₂
• Molecular Weight: 214.3227432
• Mol File: 57009-75-3.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 324.7 °C at 760 mmHg
• Flash Point: 150.2 °C
• Appearance: /
• Density: 1.233 g/cm³
• Vapor Pressure: 0.000457mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 2-(4-fluorophenyl)-1,3-dithiane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-1,3-dithiane(57009-75-3)
• EPA Substance Registry System: 2-(4-fluorophenyl)-1,3-dithiane(57009-75-3)

Safety Data

• Hazardous Substances Data: 57009-75-3(Hazardous Substances Data)

Usage

General Description

2-(4-Fluorophenyl)-1,3-dithiane is a chemical compound that belongs to the family of dithianes, which are cyclic sulfur-containing organic compounds. It is a clear, colorless liquid with a faint odor, and it is primarily used as a reagent in organic synthesis. 2-(4-Fluorophenyl)-1,3-dithiane has a 4-fluorophenyl group attached to a 1,3-dithiane ring, and it is known for its ability to undergo various reactions such as deprotection and selective functionalization. It is commonly used in the pharmaceutical and agrochemical industries for the synthesis of various biologically active compounds. Additionally, 2-(4-Fluorophenyl)-1,3-dithiane has also been studied for its potential applications in materials science and as a building block in the synthesis of complex organic molecules. Overall, this compound is a valuable reagent in organic chemistry and has a wide range of applications in various industries.

InChI:InChI=1/C10H11FS2/c11-9-4-2-8(3-5-9)10-12-6-1-7-13-10/h2-5,10H,1,6-7H2

Upstream product

• 109-80-8 1.3-propanedithiol 
• 459-57-4 4-fluorobenzaldehyde 
• 682360-46-9 2-(1,3-dithian-2-ylidene)-3-oxobutanoic acid 
• 55727-23-6 3‐(1,3-dithiane-2-yl)pentane-2,4-dione 
• 628300-14-1 2,4-dichloro-3-(1,3-propylenedithio-methylene)-penta-1,4-diene 

Downstream Products

• 144461-86-9 2-(4-fluorophenyl)-2-(α-hydroxy-4-fluorobenzyl)-1,3-dithiane 
• 725270-43-9 2-(4-fluoro)phenyl-2-triethylsilyl-1,3-dithiane 
• 1127955-55-8 2-(2-bromobenzyl)-2-(4-fluorophenyl)-1,3-dithiane 
• 1434253-88-9 C₂₁H₃₀FNO₃S₂ 
• 1043499-07-5 tert-(4R)-4-[2-(4-fluorophenyl)ethyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 1434253-96-9 2-(tert-butyloxycarbonylamino)-3-[2-(4-fluorophenyl)-1,3-dithian-2-yl]propan-1-ol 
• 1434254-20-2 tert-butyl N-[(2R)-4-(4-fluorophenyl)-1-hydroxybutan-2-yl]carbamate 
• 1434254-04-2 3-(tert-butyloxycarbonylamino)-1-(4-fluorophenyl)-4-hydroxybutan-1-one 
• 1434254-12-2 2-(tert-butyloxycarbonylamino)-4-(4-fluorophenyl)-4-oxobutanoic acid 
• 1217624-82-2 (2R)-2-{[(tert-butoxy)carbonyl]amino}-4-(4-fluorophenyl)butanoic acid 

Relevant articles and documents

Visible-Light-Induced in Situ Generation of Fischer-Type Copper Carbene Complexes from Acylsilanes and Its Application to Catalytic [4 + 1] Cycloaddition with Siloxydienes

A novel methodology for in situ generation of Fischer-type metal–carbene complexes was developed. Photoirradiation to a mixture of an acylsilane and a cationic copper complex cleanly gave a Fischer-type copper–siloxycarbene complex, which was detected by spectroscopic methods. This carbene complex reacted with siloxydienes in a [4 + 1] cycloaddition manner to give cyclopentene derivatives. It is noteworthy that this reaction proceeds with a catalytic amount of copper through in situ generation of a Fischer-type copper–siloxycarbene complex intermediate.

A 2 - substituted - 1, 3 - dithiane derivative of the preparation method

The invention provides a preparation method of a 2-substituted-1,3-dithiane derivative. The preparation method comprises the following steps: adding 1,3-dithiane (CAS:505-23-7) and 1,2-dichloroethane (DCE) or dichloromethane (DCM) into a reaction bottle, adding N-chlorosuccinimide (NCS) under ice-bath condition, and stirring for 0.5-1 h to prepare a 2-chloro-1,3-dithiane solution; and adding an aldehyde or ketone compound and a lewis acid catalyst into the above solution, and reacting to prepare the 2-substituted-1,3-dithiane derivative. By using the 1,3-dithiane solid and different types of aldehyde and keto-carbonyl compounds as raw material and using one or more of ferric trichloride, boron trifluoride diethyl etherate, methanesulfonic acid, aluminum trichloride, ferrous chloride and nickel chloride as catalysts, preparation of the 2-substituted-1,3-dithiane derivative is realized. The catalysts used in the invention are cheap and easily available, dosage of the catalysts is low and pollution of the catalysts is little. The solid raw materials used in the invention can avoid use of fetid toxic 1,3-dimercaptopropane with strong volatility, and the purpose of protecting an experimenter's body and reducing environmental pollution is realized. In addition, the preparation method has advantages of mild reaction condition, high yield, simple operation and the like.

Nickel-Catalyzed Synthesis of Silanes from Silyl Ketones

An unprecedented nickel-catalyzed decarbonylative silylation via CO extrusion intramolecular recombination fragment coupling of unstrained and nondirecting group-Assisted silyl ketones is described. The inexpensive and readily available catalyst performs