57018-10-7

Upstream product

• 6627-55-0 2-bromo-p-cresol 
• 106-44-5 p-cresol 
• 6640-27-3 2-chloro-p-cresol 

Downstream Products

• 857831-58-4 2,3-dibromo-6-chloro-4-methyl-phenol 
• 408328-16-5 2,3,5-tribromo-6-chloro-4-methyl-phenol 
• 60468-61-3 2-chloro-4-methyl-6-nitrophenol 
• 61306-41-0 2-Bromo-6-chloro-4-methoxy-4-methyl-cyclohexa-2,5-dienone 
• 57018-05-0 O,O-dimethyl O-2-bromo-4-methyl-6-chlorophenyl phosphorothioate 
• 61306-22-7 Acetic acid 3-bromo-5-chloro-1-methyl-4-oxo-cyclohexa-2,5-dienyl ester 
• 859821-73-1 2-amino-3-bromo-6-chloro-4-methyl-phenol 
• 869085-33-6 2-bromo-6-chloro-4-methylphenyl 2-propenyl ether 
• 1849-76-9 3-bromo-5-chloro-4-hydroxybenzaldehyde 
• 227766-67-8 2-(2-bromo-6-chloro-4-methyl-phenoxy)-6-chloro-4-methoxy-4-methyl-cyclohexa-2,5-dienone 
• 61305-77-9 2-Brom-6-chlor-4-hydroxy-4-methyl-cyclohexa-2,5-dienon 

Relevant academic research and scientific papers

Design, synthesis and structure–activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands

A new series of carboxyaryl-substituted phenylalanines was designed, synthesized and pharmacologically characterized in vitro at native rat ionotropic glutamate receptors as well as at cloned homomeric kainate receptors GluK1–GluK3. Among them, six compounds bound to GluK1 receptor subtypes with reasonable affinity (Kivalues in the range of 4.9–7.5?μM). A structure–activity relationship (SAR) for the obtained series, focused mainly on the pharmacological effect of structural modifications in the 4- and 5-position of the phenylalanine ring, was established. To illustrate the results, molecular docking of the synthesized series to the X-ray structure of GluK1 ligand binding core was performed. The influence of individual substituents at the phenylalanine ring for both the affinity and selectivity at AMPA, GluK1 and GluK3 receptors was analyzed, giving directions for future studies.

Intramolecular carbolithiation of allyl o-lithioaryl ethers: A new enantioselective synthesis of functionalized 2,3-dihydrobenzofurans

A new and easy method for the diastereoselective synthesis of 3-functionalized 2,3-dihydrobenzofuran derivatives from allyl 2-bromoaryl ethers is described. The key step of this transformation involves an intramolecular carbolithiation reaction of allyl 2-lithioaryl ethers. The substituents in both the allyl and the aryl moieties play an important and decisive role in stopping the reaction at the benzofuran thus avoiding a γ-elimination reaction. Finally, this process is amenable to the synthesis of enantiomerically enriched compounds by using ( - )-sparteine as a chiral inductor.