57022-36-3

Basic information

• Product Name: Carbonocyanidic acid, (4-methoxyphenyl)methyl ester
• CAS NO: 57022-36-3
• Molecular Formula: C10H9NO3
• Molecular Weight: 191.186
• Mol File: 57022-36-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbonocyanidic acid, (4-methoxyphenyl)methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbonocyanidic acid, (4-methoxyphenyl)methyl ester(57022-36-3)
• EPA Substance Registry System: Carbonocyanidic acid, (4-methoxyphenyl)methyl ester(57022-36-3)

Safety Data

• Hazardous Substances Data: 57022-36-3(Hazardous Substances Data)

Upstream product

• 61312-35-4 4-methoxybenzyl 3-oxobutanoate 

Downstream Products

• 111948-92-6 2-Butyl-malonic acid 4-methoxy-benzyl ester methyl ester 
• 111948-89-1 4-methoxybenzyl 2-oxocyclohexanecarboxylate 
• 111973-96-7 2-Methyl-6-oxo-cyclohexanecarboxylic acid 4-methoxy-benzyl ester 
• 111973-97-8 2-Methyl-5-oxo-cyclopentanecarboxylic acid 4-methoxy-benzyl ester 
• 111948-88-0 3-Oxo-nonanoic acid 4-methoxy-benzyl ester 
• 111948-90-4 2-Oxo-cyclopentanecarboxylic acid 4-methoxy-benzyl ester 
• 111948-93-7 2-Oxo-cyclohexane-1,3-dicarboxylic acid 1-(4-methoxy-benzyl) ester 3-methyl ester 
• 112018-82-3 6a-Hex-5-enyl-1-oxo-octahydro-pentalene-2-carboxylic acid 4-methoxy-benzyl ester 
• 111948-91-5 Cyclohexane-1,1-dicarboxylic acid 4-methoxy-benzyl ester methyl ester 

Relevant articles and documents

An expedient synthesis of cyanoformates via DAST-mediated C–C bond cleavage of α-oximino-β-ketoesters

A new protocol to synthesize cyanoformates was developed using simple β-ketoesters as substrates. (Diethylamino)sulfur trifluoride (DAST) was used as a dual-role reagent to activate the oxime moiety and to donate a fluoride. The key intermediates, α-oximino-β-ketoesters, were prepared by highly efficient acid-assisted oximation of β-ketoesters. Then, the deconstruction of α-oximino-β-ketoesters by the fluorinative C–C bond cleavage was demonstrated to provide cyanoformates. In this event, the fluoride addition followed by the C–C bond cleavage selectively occurred in the ketones over esters. Due to simple and mild reaction conditions, variously functionalized cyanoformates were exemplified.