57024-92-7Relevant academic research and scientific papers
Triply Convergent, Stereospecific Alkene Formation via Peterson Olefination
Barrett, Anthony G. M.,Flygare, John A.
, p. 638 - 642 (2007/10/02)
α-Iodo silanes 8 were prepared from α-hydroxy silanes and after halogen/metal exchange and treatment with copper(I)bromide-dimethyl sulfide were coupled with acid chlorides to yield α-silyl ketones 2.Cram controlled addition with a variety of nucleophiles followed by treatment with acid or base led to either the (E)- or (Z)-alkene in good overall yields from the iodide (47-67percent) and with excellent stereoselectivities (>95/95/5 isomeric purity.
