5703-61-7Relevant academic research and scientific papers
Nickel-Catalyzed Deaminative Cyanation: Nitriles and One-Carbon Homologation from Alkyl Amines
Xu, Jianyu,Twitty, J. Cameron,Watson, Mary P.
supporting information, p. 6242 - 6245 (2021/08/23)
A nickel-catalyzed deaminative cyanation of Katritzky pyridinium salts has been developed. When it is coupled with formation of the pyridinium salt from primary amines, this method enables alkyl amines to be converted to alkyl nitriles. A less toxic cyanide reagent, Zn(CN)2, is utilized, and diverse functional groups and heterocycles are tolerated. The method also enables a one-carbon homologation of alkyl amines via reduction of the nitrile products, in addition to many other potential transformations of the versatile nitrile group.
Thiocyanate radical mediated dehydration of aldoximes with visible light and air
Ban, Yong-Liang,Dai, Jian-Ling,Jin, Xiao-Ling,Zhang, Qing-Bao,Liu, Qiang
supporting information, p. 9701 - 9704 (2019/08/15)
We developed a new means of activating aldoximes by an in situ generated thiocyanate radical from ammonium thiocyanate and molecular oxygen at room temperature. With a catalytic amount of organic dye aizenuranine as the photocatalyst, the dehydration of aldoximes proceeds smoothly under visible light irradiation, providing a simple to handle, excellent functional group tolerance, and metal-free protocol for a wide range of nitriles.
Green synthesis process of berberine
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Paragraph 0026; 0029; 0030, (2018/09/08)
The invention discloses a green synthesis process of berberine. The synthesis process comprises the following steps: firstly, introducing dichloromethane into N,N-dimethylformamide by adopting catechol under the alkaline condition and reacting to synthesize benzodioxole; secondly, preparing pepper propionitrile by utilizing the obtained benzodioxole, preparing pepper propionamide by utilizing obtained pepper propionitrile, preparing homopiperony lamine by utilizing pepper propionamide and then synthesizing N-2,3-dimethoxybenzyl homopiperony lamine hydrochloride; finally, synthesizing berberinehydrochloride by utilizing the N-2,3-dimethoxybenzyl homopiperony lamine hydrochloride under the condition of glyoxal, formic acid and copper sulfate. The green synthesis process of the berberine, disclosed by the invention, has the advantages that the formation of black polymers is reduced, the reaction yield is improved, the problem that environmental pollution caused by a large amount of the black polymers produced in the original process production is solved and the requirements of green chemical synthesis required by China are met.
Transformation of oximes of phenetyl ketone derivatives to quinolines and azaspirotrienones catalyzed by tetrabutylammonium perrhenate and trifluoromethanesulfonic acid
Kusama,Yamashita,Uchiyama,Narasaka
, p. 965 - 975 (2007/10/03)
Phenethyl ketone oximes are converted to quinolines by the treatment with tetrabutylammonium perrhenate, trifluoromethanesulfonic acid, and chloranil in refluxing 1,2-dichloroethane. Azaspirotrienones can be synthesized from p-hydroxyphenethyl or 3-(p-hydroxyphenyl)propyl ketone oximes by applying the above method. Thus prepared azaspirotrienones are converted to quinolines by acid treatment.
The reduction of α,β-unsaturated nitriles and α-halonitriles with sodium hydrogen telluride
Blay, Gonzalo,Cardona, Luz,Garcia, Begona,Lahoz, Luisa,Pedro, Jose R.
, p. 8611 - 8618 (2007/10/03)
Sodium hydrogen telluride reacts chemoselectively with α,β- unsaturated nitriles and α-halonitriles linked to aromatic and aliphatic substituents to corresponding saturated nitriles with good yields.
