570360-91-7Relevant academic research and scientific papers
Simple one-pot synthesis of 5-(chloromethyl)isoxazoles from aldoximes and 2,3-dichloro-1-propene
Kondrashov, Evgeniy V.,Shatokhina, Nina S.
, p. 1228 - 1232 (2020/01/08)
[Figure not available: see fulltext.] A one-pot synthesis of 3-substituted 5-chloromethylisoxazoles from available starting aldoximes and 2,3-dichloro-1-propene, serving both as a solvent and reagent, is proposed. Excess 2,3-dichloro-1-propene is recovered after the reaction. The synthesis is effective for oximes of both aromatic and aliphatic aldehydes.
Synthesis and biological evaluation of isoxazolyl-sulfonamides: A non-cytotoxic scaffold active against Trypanosoma cruzi, Leishmania amazonensis and Herpes Simplex Virus
da Rosa, Rafael,Zimmermann, Lara Almida,de Moraes, Milene H?ehr,Schneider, Naira Fernanda Zanchett,Schappo, Alice Duarte,Sim?es, Claudia Maria de Oliveira,Steindel, Mario,Schenkel, Eloir Paulo,Bernardes, Lílian Sibelle Campos
supporting information, p. 3381 - 3384 (2018/09/11)
In this study we report the synthesis, characterization, biological evaluation, and druglikeness assessment of a series of 20 novel isoxazolyl-sulfonamides, obtained by a four-step synthetic route. The compounds had their activity against Trypanosoma cruz
Processes For The Preparation Of Anti-Viral Compounds And Compositions Containing Them
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Page/Page column 80, (2010/03/02)
Disclosed are processes for the preparation of compounds of formula I and compositions that comprise said compounds of formula I. Also disclosed are processes for the preparation of compounds of formula III and compositions that comprise said compounds of formula III.
ANTI-VIRAL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
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Page/Page column 62, (2009/03/07)
Disclosed are compounds of Formula (I), pharmaceutically acceptable salts and solvates thereof, compositions thereof, and methods for their preparation and uses for treating viral infections mediated at least in part by a virus in the Flaviviridae family of viruses. (I)
