570373-45-4

Basic information

• Product Name: 2-chloro-N-[3-[(3’-chloro[1,1’-biphenyl]-4-yl)methyl]-3,4-dihydro-4-oxo-2-propyl-6-quinazolinyl]benzamide
• Synonyms: 2-chloro-N-[3-[(3’-chloro[1,1’-biphenyl]-4-yl)methyl]-3,4-dihydro-4-oxo-2-propyl-6-quinazolinyl]benzamide
• CAS NO: 570373-45-4
• Molecular Weight: 542.464
• Mol File: 570373-45-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-chloro-N-[3-[(3’-chloro[1,1’-biphenyl]-4-yl)methyl]-3,4-dihydro-4-oxo-2-propyl-6-quinazolinyl]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-[3-[(3’-chloro[1,1’-biphenyl]-4-yl)methyl]-3,4-dihydro-4-oxo-2-propyl-6-quinazolinyl]benzamide(570373-45-4)
• EPA Substance Registry System: 2-chloro-N-[3-[(3’-chloro[1,1’-biphenyl]-4-yl)methyl]-3,4-dihydro-4-oxo-2-propyl-6-quinazolinyl]benzamide(570373-45-4)

Safety Data

• Hazardous Substances Data: 570373-45-4(Hazardous Substances Data)

Upstream product

• 1211594-36-3 (3′-chlorobiphenyl-4-yl)methylammonium chloride 
• 609-66-5 2-chlorobenzamide 
• 116027-10-2 5-iodoisatoic anhydride 

Relevant articles and documents

Preparation microsomal prostaglandin E2 synthase -1 inhibitors

The invention discloses a method for preparing microsomal prostaglandin E2 synthase - 1 inhibitors. Comprises three steps: 1) 5 - iodine isatin anhydride with 4 - (3 - chlorophenyl) of Ssri hydrochloride preparation N - substituted amide; 2) N - substituted amide with crotyl alcohol generating 3 - [(3 '- chloro [1, 1' - diphenyl] - 4 - yl) methyl] - 2 - propyl - 6 - [...]; 3) a step of O-benzamide in product and then Goldberg amination reaction to obtain the target product. The preparation step of the method is simple, avoids the use of alkali and toxic chemical reagent, such as triphenyl phosphate, crotyl alcohol to a readily available and inexpensive raw materials, [...] transfer, the reaction process is not alkali, "one-pot" reaction is completed, the by-product is only water, reaction the atom economy is high, consistent with the requirement of green chemistry, has broad prospects of development.