570424-28-1

Basic information

• Product Name: 5-chloro-3-[4-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-2-phenyl-3H-imidazole-4-carbaldehyde
• Synonyms: 5-chloro-3-[4-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-2-phenyl-3H-imidazole-4-carbaldehyde
• CAS NO: 570424-28-1
• Molecular Weight: 408.692
• Mol File: 570424-28-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-chloro-3-[4-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-2-phenyl-3H-imidazole-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-3-[4-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-2-phenyl-3H-imidazole-4-carbaldehyde(570424-28-1)
• EPA Substance Registry System: 5-chloro-3-[4-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl]-2-phenyl-3H-imidazole-4-carbaldehyde(570424-28-1)

Safety Data

• Hazardous Substances Data: 570424-28-1(Hazardous Substances Data)

Upstream product

• 380481-66-3 5,5-dimethyl-2-(4-methylphenyl)-1,3,2-dioxaborinane 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 106-38-7 para-bromotoluene 
• 60367-52-4 5-chloro-2-phenyl-3H-imidazole-4-carbaldehyde 
• 143805-78-1 2-(4-bromomethyl-phenyl)-5,5-dimethyl-[1,3,2]dioxaborinane 

Downstream Products

• 570424-32-7 3-[4-(4-chloro-5-formyl-2-phenyl-imidazol-1-ylmethyl)phenyl]-5-isobutylthiophene-2-(3-ethyl) sulfonylurea 

Relevant articles and documents

14C-labeled and large-scale synthesis of the angiotensin-(1-7)-receptor agonist AVE 0991 by cross-coupling reactions.

The synthesis of (14)C-labeled AVE 0991 ((14)()C-1a) and large-scale synthesis of AVE 0991 (1a) are described. In the key step of the synthesis, the C-C coupling reaction of the imidazole (2) and thiophene (3) building blocks was studied under Suzuki and Stille reaction conditions, respectively. Suzuki reaction gave only moderate yields, whereas the best results were obtained under Stille reaction conditions with up to 64% yield.