57045-15-5

Upstream product

• 1077-16-3 hexylbenzene 
• 141-82-2 malonic acid 
• 49763-69-1 4-hexylbenzaldehyde 

Downstream Products

• 54256-25-6 p-hexylcinnamoyl chloride 
• 110683-44-8 (E)-3-(4-Hexyl-phenyl)-N-[3-(1H-tetrazol-5-yl)-2,3-dihydro-benzo[1,4]dioxin-5-yl]-acrylamide 
• 110683-53-9 (E)-3-(4-Hexyl-phenyl)-N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-chromen-8-yl]-acrylamide 

Relevant academic research and scientific papers

Synthesis of p-Alkyl-, p-Alkoxy-, and p-Acyloxycinnamates with trans-4-Phenylcyclohexyl and 4-Biphenylyl Fragments and Their Mesomorphic Properties

Acylation of trans-4-phenylcyclohexanol and p-cyano-p'-hydroxybiphenyl with p-n-alkyl-, p-n-alkoxy-, and p-n-alkanoyloxycinnamoyl chlorides yields corresponding cinnamates.

New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships

(p-Amylcinnamoyl)anthranilic acid (3a) had moderate antagonist activities against LTD4-induced smooth muscle contraction on guinea pig ileum and LTC4-induced bronchoconstriction in anesthetized guinea pigs. Modifications were made in the hydrophobic part (cinnamoyl moiety) and the hydrophilic part (anthranilate moiety) of 3a. A series of 8-(benzoylamino)-2-tetrazol-5-yl-1,4-benzodioxans and 8-(benzoylamino)-2-tetrazol-5-yl-4-oxo-4H-1-benzopyrans were revealed to be potent antagonists of leukotrienes C4 and D4. Among both series, ONO-RS-347 (18k) and ONO-RS411 (19h) were the most potent and orally active antagonists, respectively. Structure-activity relationships are discussed.

Phenyl-pyrimidines

Phenyl-pyrimidines of the formula STR1 wherein R1 and R2 are as hereinafter set forth, are described. The end products are useful as liquid crystals.