49763-69-1

Usage

Uses

Used in Food and Beverage Industry:
4-N-HEXYLBENZALDEHYDE is used as a flavoring agent for adding a nutty and sweet aroma to a variety of food and beverage products, enhancing their sensory appeal.
Used in Fragrance Industry:
In the fragrance industry, 4-N-HEXYLBENZALDEHYDE serves as a key ingredient in the production of perfumes and colognes, contributing to their unique and pleasant scents.
Used in Pharmaceutical Manufacturing:
4-N-HEXYLBENZALDEHYDE is utilized in the manufacturing of pharmaceuticals, playing a crucial role in the development of various medicinal products.
Used as an Intermediate in Organic Synthesis:
This chemical compound also functions as an intermediate in organic synthesis, facilitating the creation of other complex organic molecules for a range of applications across different industries.

InChI:InChI=1/C13H18O/c1-2-3-4-5-6-12-7-9-13(11-14)10-8-12/h7-11H,2-6H2,1H3

Upstream product

• 542-88-1 bis(2-chloromethyl)ether 
• 1077-16-3 hexylbenzene 
• 79-37-8 oxalyl dichloride 
• 50606-95-6 4-hexylbenzoyl chloride 
• 4885-02-3 Dichloromethyl methyl ether 
• 100-97-0 hexamethylenetetramine 
• 2591-86-8 N-Formylpiperidine 
• 62150-34-9 1-n-hexyl-4-iodobenzene 
• 89511-01-3 p-n-hexylbenzaldehyde diethylacetal 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 96164-66-8 hexyltrifluorosilane 
• 25891-31-0 triformylamine 
• 332047-72-0 tris(diformylamino)methane 
• 928-65-4 hexyltrichlorosilane 

Downstream Products

• 57045-15-5 p-Hexylzimtsaeure 
• 69824-76-6 2,5-bis-(4-hexyl-phenyl)-thiazolo[5,4-d]thiazole 
• 72739-41-4 3-[(E)-3-(4-Hexyl-phenyl)-acryloyl]-4-hydroxy-benzoic acid 
• 74800-75-2 2-(4-Hexyl-phenyl)-5-octyl-[1,3]dioxane 
• 81231-45-0 2-(4-Hexyl-phenyl)-5-octyl-[1,3]dioxane 
• 74800-74-1 5-Heptyl-2-(4-hexyl-phenyl)-[1,3]dioxane 
• 81220-94-2 5-Heptyl-2-(4-hexyl-phenyl)-[1,3]dioxane 
• 57045-15-5 p-hexylcinnamic acid 
• 74813-24-4 5-Hexyl-2-(4-hexyl-phenyl)-[1,3]dioxane 
• 81220-93-1 5-Hexyl-2-(4-hexyl-phenyl)-[1,3]dioxane 
• 21643-38-9 4-hexylbenzoic acid 
• 110417-74-8 4-[(2R,3R)-3-(4-Hexyl-phenyl)-oxiranesulfonyl]-morpholine 
• 166964-87-0 4-n-Hexyl-β,β'-dibromostyrene 

Relevant academic research and scientific papers

Scalable Negishi Coupling between Organozinc Compounds and (Hetero)Aryl Bromides under Aerobic Conditions when using Bulk Water or Deep Eutectic Solvents with no Additional Ligands

Pd-catalyzed Negishi cross-coupling reactions between organozinc compounds and (hetero)aryl bromides have been reported when using bulk water as the reaction medium in the presence of NaCl or the biodegradable choline chloride/urea eutectic mixture. Both C(sp3)-C(sp2) and C(sp2)-C(sp2) couplings have been found to proceed smoothly, with high chemoselectivity, under mild conditions (room temperature or 60 °C) in air, and in competition with protonolysis. Additional benefits include very short reaction times (20 s), good to excellent yields (up to 98 %), wide substrate scope, and the tolerance of a variety of functional groups. The proposed novel protocol is scalable, and the practicability of the method is further highlighted by an easy recycling of both the catalyst and the eutectic mixture or water.

RATIONALLY DESIGNED LAWSONE DERIVATIVES AS ANTIMICROBIALS AGAINST MULTIDRUG-RESISTANT STAPHYLOCOCCUS AUREUS

Naphthoquinone derivatives of Lawsone have been found to be effective against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). Such compounds generally contain a substituent group at the 3-position of a specific naphthoquinone compound, i.e. 2-hydroxy-1,4-naphthoquinone. One of these derivatives referred to as compound 6c in the series exhibits potent antimicrobial activity that is comparable to that of the two commercial antibiotics ofloxacin and ciprofloxacin against the two strains of methicillin sensitive Staphylococcus aureus (MSSA; ATCC 29213 and ATCC 6538). In the case of two strains of MRSA (ATCC BAA-44 and ATCC BAA-1717) that have developed drug resistance to both ofloxacin and ciprofloxacin, the antimicrobial activity of 6c can almost rival that of vancomycin and daptomycin. Furthermore, 6c is also effective against vancomycin-intermediate and daptomycin non-susceptible strain of MRSA (ATCC 700699). Besides the efficacy, 6c has a much improved drug resistance profile in comparison with the conventional antibiotics.

Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase

Type I signal peptidase, with its vital role in bacterial viability, is a promising but underexploited antibacterial drug target. In the light of steadily increasing rates of antimicrobial resistance, we have developed novel macrocyclic lipopeptides, linking P2 and P1′ by a boronic ester warhead, capable of inhibiting Escherichia coli type I signal peptidase (EcLepB) and exhibiting good antibacterial activity. Structural modifications of the macrocyclic ring, the peptide sequence and the lipophilic tail led us to 14 novel macrocyclic boronic esters. It could be shown that macrocyclization is well tolerated in terms of EcLepB inhibition and antibacterial activity. Among the synthesized macrocycles, potent enzyme inhibitors in the low nanomolar range (e.g. compound 42f, EcLepB IC50 = 29 nM) were identified also showing good antimicrobial activity (e.g. compound 42b, E. coli WT MIC = 16 μg/mL). The unique macrocyclic boronic esters described here were based on previously published linear lipopeptidic EcLepB inhibitors in an attempt to address cytotoxicity and hemolysis. We show herein that structural changes to the macrocyclic ring influence both the cytotoxicity and hemolytic activity suggesting that the P2 to P1’ linker provide means for optimizing off-target effects. However, for the present set of compounds we were not able to separate the antibacterial activity and cytotoxic effect.

Metal-catalyzed formal amidation of alkenes under CO-free condition

An effective procedure for synthesis of amides from alkenes and [Formula presented] via Pd and Fe catalysts under mild conditions is described. A series of benzamides containing various functional groups can be obtained in reasonable yield and the possible reaction pathway is proposed in this Letter.

An unsymmetrically π-extended porphyrin-based single-crystal field-effect transistor and its anisotropic carrier-transport behavior

Anisotropic charge transport: Single-crystal organic field-effect transistor devices derived from aggregates of thiophene-appended porphyrins display very high mobility (0.27 cm2 V-1 s-1). This behavior is due to staircase stacking of the porphyrins with distances between layers of 3.17(7) A. Furthermore, the charge-transport behavior is anisotropic owing to an anisotropic molecular arrangement in the single-crystal microplates. Copyright

Dramatic enhancement of carrier mobility via effective secondary structural arrangement resulting from the substituents in a porphyrin transistor

OFET devices based on single-crystals of two different porphyrin derivatives display excellent mobilities of 2.57 and 0.48 cm2 V -1 s-1. Although they generate similar J-aggregations, the dramatic enhancement of mobility obtained using porphyrin 1 is due to the well-confined secondary structural arrangement caused by substituents on the porphyrin ring.

Antimycobacterial activity evaluation, time-kill kinetic and 3D-QSAR study of C-(3-aminomethyl-cyclohexyl)-methylamine derivatives

A series of C-(3-aminomethyl-cyclohexyl)-methylamine derivatives were synthesized and evaluated for their antitubercular activity. Some of the compounds exhibited potent activity against Mycobacterium tuberculosis H37Rv. One of the compound having t-butyl at para position of the benzene ring showed excellent activity even better than the standard drug ethambutol with MIC value 1.1 ± 0.2 μM. The time-kill kinetics study of two most active compounds showed rapid killing of the M. tuberculosis within 4 days. Additionally atom-based quantitative structure-activity relationship (QSAR) model was developed that gave a statistically satisfying result (R2) = 0.92, Q2 = 0.75, Pearson-R = 0.96 and effectively predicts the anti-tuberculosis activity of training and test set compounds.

Heteroaromatic moieties in the sphingosine backbone of α- Galactosylceramides for noncovalent interactions with CD1d

A series of α-GalCer analogues containing heterocyclic and aromatic moieties in the sphingosine backbone were synthesized to improve the selectivity in the Th1/Th2 cytokine profile via noncovalent interaction with three aromatic residues at the binding pocket of CD1d. In vitro and in vivo biological evaluations revealed the treatment of α-GalCer analogue (6) induced the selective stimulation of natural killer T cells to facilitate the secretion of Th2 cytokines.

COMPOSITIONS AND METHODS FOR INHIBITING SPHINGOSINE KINASE

Amidine analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 and SphK2) are provided. The compounds can prevent angiogenesis in tumor cells.

Orthoamides, LIX [1]. Formyl-aalen [tris(diformylamino)methane] - A new formylating reagent for activated aromatic compounds

In the presence of strong Lewis acids such as aluminum chloride or boron trichloride, formyl-aalen [tris(diformylamino)methane] (3) acts as a formylating reagent for aromatic alkane compounds and aromatic ethers. The orthoamide 3 delivers three formyl groups for the formylation process. Thus toluene, cumene, tert-butylbenzene, hexylbenzene, o-xylene, p-cymene, biphenyl, anisole, diphenylether and 1,3-dimethoxybenzene can be formylated in 1,2-dichloroethane. In these reactions, 3 and aluminum chloride should be used in a molar ratio of 1:6 to 1:9.