57045-82-6

Basic information

• Product Name: CHLOROFORMIC ACID N-NONYL ESTER
• Synonyms: CHLOROFORMIC ACID N-NONYL ESTER;CHLOROFORMIC ACID NONYL ESTER;NONYL CHLOROFORMATE;Nonyl chloridocarbonate
• CAS NO: 57045-82-6
• Molecular Formula: C₁₀H₁₉ClO₂
• Molecular Weight: 206.71
• Mol File: 57045-82-6.mol

Chemical Properties

• Boiling Point: 248.2°C at 760 mmHg
• Flash Point: 79.6°C
• Appearance: /
• Density: 0.97
• Vapor Pressure: 0.0245mmHg at 25°C
• Refractive Index: 1.4330-1.4360
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: CHLOROFORMIC ACID N-NONYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: CHLOROFORMIC ACID N-NONYL ESTER(57045-82-6)
• EPA Substance Registry System: CHLOROFORMIC ACID N-NONYL ESTER(57045-82-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• RIDADR: 2742
• HazardClass: 6.1/8
• PackingGroup: II
• Hazardous Substances Data: 57045-82-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Chloroformic acid N-nonyl ester is used as a reagent in organic synthesis for the production of various organic compounds. Its high reactivity allows it to participate in a wide range of chemical reactions, making it a versatile component in the synthesis of different molecules.
Used in Pharmaceutical Production:
In the pharmaceutical industry, nonyl chloroformate is used as an intermediate in the production of various pharmaceuticals. Its ability to participate in organic synthesis makes it a valuable component in the development of new drugs and medications.
Used in Agrochemical Production:
Chloroformic acid N-nonyl ester is also used as an intermediate in the production of agrochemicals, such as pesticides and herbicides. Its role in organic synthesis contributes to the development of effective and efficient agricultural chemicals.
Used in Dye Production:
Nonyl chloroformate is utilized in the production of dyes, where its reactivity and properties contribute to the creation of a variety of colorants for different applications.
Used in Perfume Production:
In the perfume industry, chloroformic acid N-nonyl ester is used in the synthesis of various fragrances. Its ability to participate in organic reactions allows for the creation of unique and complex scents.
Safety Precautions:
Due to its potential as a skin and eye irritant, nonyl chloroformate should be handled with care in laboratory or industrial settings. Proper safety measures, such as wearing protective gear and working in well-ventilated areas, should be taken to minimize exposure and potential hazards.

InChI:InChI=1/C10H19ClO2/c1-2-3-4-5-6-7-8-9-13-10(11)12/h2-9H2,1H3

Upstream product

• 75-44-5 phosgene 
• 143-08-8 nonyl alcohol 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 121679-83-2 Carbonic acid nonyl ester 4-[5-(4-nonyloxy-phenyl)-[1,3,4]thiadiazol-2-yl]-phenyl ester 
• 1380431-41-3 nonyl 4,5-dimethoxy-2-nitrobenzylcarbamate 

Relevant articles and documents

Anti-HIV-Active Nucleoside Triphosphate Prodrugs

We disclose a study on nucleoside triphosphate (NTP) analogues in which the γ-phosphate is covalently modified by two different biodegradable masking units and d4T as nucleoside analogue that enable the delivery of d4TTP with high selectivity in phosphate buffer (pH 7.3) and by enzyme-triggered reactions in human CD4+ T-lymphocyte CEM cell extracts. This allows the bypass of all steps normally needed in the intracellular phosphorylation. These TriPPPro-nucleotides comprising an acyloxybenzyl (AB; ester) or an alkoxycarbonyloxybenzyl (ACB; carbonate) in combination with an ACB moiety are described as NTP delivery systems. The introduction of these two different groups led to the selective formation of γ-(ACB)-d4TTPs by chemical hydrolysis and in particular by cell extract enzymes. γ-(AB)-d4TTPs are faster cleaved than γ-(ACB)-d4TTPs. In antiviral assays, the compounds are highly active against HIV-1 and HIV-2 in wild-type CEM/O cells and more importantly in thymidine kinase-deficient CD4+ T-cells (CEM/TK-).

Photolysis of ortho-nitrobenzylic derivatives: The importance of the leaving group

Quantum yields for the photoinduced release of seven different commonly used leaving groups (LGs) from the o-nitroveratryl protecting group were measured. It was found that these quantum yields depend strongly on the nature of the LGs. We show that the quantum efficiency with which the LGs are released correlates with the stabilization that these LGs provide to o-nitrobenzyl-type radicals because radical stabilizing groups weaken the C-H bond that is cleaved in the photoinduced hydrogen atom transfer step, and hence lower the barrier for this process. At the same time these substituents lower the endothermicity of the thermal hydrogen atom transfer and thus increase the barrier for the reverse process, thereby enhancing the part of the initially formed aci-nitro intermediates which undergo cyclization (which ultimately leads to LG release). Radical stabilization energies computed by DFT methods are thus a useful predictor of the relative efficiency with which LGs are photoreleased from o-nitrobenzyl protecting groups.

Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase

Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparation of medicaments useful in the pathologies related to a hyperactivity of carnitine palmitoyl-transferase, such as hyperglycemia, diabetes and pathologies related thereto, heart failure, ischemia.