57051-20-4

Basic information

• Product Name: 4-hydroxycrotonamide
• Synonyms: 4-hydroxycrotonamide
• CAS NO: 57051-20-4
• Molecular Weight: 101.105
• Mol File: 57051-20-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-hydroxycrotonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxycrotonamide(57051-20-4)
• EPA Substance Registry System: 4-hydroxycrotonamide(57051-20-4)

Safety Data

• Hazardous Substances Data: 57051-20-4(Hazardous Substances Data)

Upstream product

• 51499-71-9 4-chloro-3-hydroxybutylamide 
• 75-50-3 trimethylamine 

Relevant articles and documents

PROCESS FOR PRODUCTION OF BETAINE

According to the present invention, by using 4-halogeno-3-hydroxybutanamide as a substrate in quaternary amination reaction with trialkylamine which is an important step in betaine (such as carnitine) preparation processes, it becomes possible to reduce the production of crotonic acid derivatives (the major by-product) greatly compared to conventional processes. Consequently, it becomes possible to prepare a betaine, such as carnitine, at a high yield. The present invention also relates to a process for preparing a betaine represented by formula (1) below, comprising a step of quaternary aminating an amide represented by formula (2) below: wherein A1, A2 and A3 individually represent a C1-C20 hydrocarbon group which may have a substituent(s); and X1 is a halogen atom.