5707-05-1

Upstream product

• 34837-55-3 Phenylselenyl bromide 
• 121-45-9 phosphorous acid trimethyl ester 
• 1666-13-3 diphenyl diselenide 
• 868-85-9 Dimethyl phosphite 
• 17201-06-8 sodium dimethyl phosphonate 
• 5707-06-2 O,O-diethyl Se-phenyl phosphoroselenoate 
• 645-96-5 Benzeneselenol 
• 5707-04-0 Phenylselenyl chloride 

Relevant academic research and scientific papers

A greener protocol for the synthesis of phosphorochalcogenoates: Antioxidant and free radical scavenging activities

In this contribution, a metal- and base-free protocol has been developed for the synthesis of phosphorochalcogenoates (Se and Te) by using DMSO as solvent at 50 °C. A variety of phosphorochalcogenoates were prepared from diorganyl dichalcogenides and H-phosphonates, leading to the formation of a Chal-P(O) bond, in a rapid procedure with good to excellent yields. A full structural elucidation of products was accessed by 1D and 2D NMR, IR, CGMS, and HRMS analyses, and a stability evaluation of the phosphorochalcogenoates was performed for an effective operational description of this simple and feasible method. Typical 77Se{1H} (δSe = 866.0 ppm), 125Te{1H} (δTe = 422.0 ppm) and 31P{1H} (δP = ?1.0, ?13.0 and ?15.0 ppm) NMR chemical shifts were imperative to confirm the byproducts, in which this stability study was also important to select some products for pharmacological screening. The phosphorochalcogenoates were screened in vitro and ex vivo tests for the antioxidant potential and free radical scavenging activity, as well as to investigation toxicity in mice through of the plasma levels of markers of renal and hepatic damage. The pharmacological screening of phosphorochalcogenoates indicated that compounds have antioxidant propriety in different assays and not changes plasma levels of markers of renal and hepatic damage, with excision of 3g compound that increased plasma creatinine levels and decreased plasma urea levels when compared to control group in the blood mice. Thus, these compounds can be promising synthetic antioxidants that provide protection against oxidative diseases.

Electrochemical selenation of phosphonates and phosphine oxides

An environmentally friendly electrocatalytic strategy for the synthesis of organoselenophospho-rus between phosphonates /phosphine oxides and selenols/diselenides is reported. The reaction was performed with metal-, base- and oxidant-free at room temperat

Accelerating Electrochemical Synthesis through Automated Flow: Efficient Synthesis of Chalcogenophosphites

Integrated electrochemical reactors in automated flow systems have been utilised for chalcogenophosphite formations. Multiple electrochemical reactions can be performed using a programmed sequence in a fully autonomous way. Differently functionalised chal

Atom-economical selenation of electron-rich arenes and phosphonates with molecular oxygen at room temperature

Organoselenium and selenophosphorus compounds are ubiquitously found in biologically active compounds, agrochemicals, functionalized materials etc. Although selenium is a micronutrient and an essential trace element, its contamination/consumption in highe

Calix[4]arene-assisted KOH-catalyzed synthesis of O,O-dialkyl-Se-aryl phosphoroselenoates

A convenient and efficient method for the synthesis of O,O-dialkyl-Se-aryl phosphoroselenoates is described via a one pot reaction of diaryl diselenide and O,O-dialkylphosphonate catalyzed by KOH assisted by a co-catalyst of calix[4]arene 3. The calix[4]a

Environmentally benign synthesis and antimicrobial study of novel chalcogenophosphates

We report in this work an environmentally benign zinc mediated synthesis of aryl and benzyl phosphorochalcogenoates in ethanol within a short reaction time. In vitro antimicrobial study along with statistical analysis and seed germination assay were perfo

A novel and general method for the formation of S-aryl, Se-aryl, and Te-aryl phosphorochalcogenoates

A new and general method for the synthesis of S-, Se-, and Te-aryl phosphorochalcogenoates (chalcogenophosphates) has been developed. S-P, Se-P, and Te-P bonds were formed by the coupling of readily available dialkyl phosphites with diaryl dichalcogenides at 30°C in dimethyl sulfoxide in the presence of catalytic amounts of copper iodide and diethylamine. The reaction proceeded smoothly without exclusion of moisture or air. Georg Thieme Verlag Stuttgart.

Free radical reaction of dialkyl phosphites and organic dichalcogenides: A new facile and convenient preparation of arylselenophosphates

Azobisisobutyronitrile-initiated free radical reaction of dialkyl phosphites with diaryl diselenides afforded arylselenophosphates in high yields. Arylthiophosphates and aryltellurophosphates can also be synthesized by similar reaction of diaryl disulfide

Hypervalent iodine in synthesis. 49. A new effective synthesis of Se-phenyl O,O-dialkyl phosphoroselenoates with polymer-supported phenyliodine diacetate

Se-phenyl O,O-dialkyl phosphoroselenoates have been prepared by the one-pot reaction of sodium O,O-dialkyl phosphorates, diphenyl diselenide, and polymer-supported phenyliodine diacetate (PPID).

Hypervalent iodine in synthesis 51: A facile novel synthetic access to Se-phenyl O,O-dialkyl phosphoroselenoates

O,O-Dialkyl phosphorous acids react at room temperature with phenyliodine diacetate (PID), sodium azide and diphenyl diselenide, to afford Se-phenyl O,O-dialkyl phosphoroselenoates in good yields.